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ProteomicsFrancisella tularensis virulence is dependent on a conserved putative catalytic triad within the Type VI secretion system component PdpC
Many Gram-negative bacteria utilize the ubiquitous and versatile type VI secretion systems (T6SS) for diverse purposes, such as outcompeting other microbes or to successfully colonize hosts. T6SS of common pathogens are classified as T6SSi, but an outlier is the T6SSii and it is present only in the ...
ORGANISM(S): Francisella tularensis subsp. novicida (strain U112) 
2026-03-09 | PXD059583 | Pride
Virulence Type vi secretion system Amino acid triad Francisella tularensis Pdpc 
TranscriptomicsTranscription profiling by array of cells starved of leucine in the presence or absence of a dominant negative HSF1 mutant (dnHSF1, HSF379).
Cells were starved for leucine in the presence or absence of a dominant negative HSF1 mutant (dnHSF1, HSF379). Changes in transcriptome relative to cells cultured with leucine were determined. The experiment shows the effect of dnHSF on the amino acid starvation response.
ORGANISM(S): Homo sapiens 
2012-12-11 | E-MEXP-3563 | biostudies-arrayexpress
TranscriptomicsAmpliSeq Data of WT and SLC38A10 knockout primary cortex cells in amino acid starvation and refed conditions
Samples-WT Basal condition primary cortex cells; WT B27 Starved-Primary cortex cells starved overnight without B27 supplement media. WT AA Starved-Primary cortex cell starved without amino acid for 2 hours. WT AA Refed-Primary cortex cell refed for 1 hour after amino acid starvation. KO Basal-SLC38 ...
ORGANISM(S): Mus musculus 
2021-06-03 | E-MTAB-10413 | biostudies-arrayexpress
ProteomicsProteomics of HeLa cells starved and treated with YWF or leptomycin B
HeLa cells labeled with SILAC and were amino acids starved and treated with YWF, leptomycin B, MG132 or chloroquine. Cells were lysed with a 8M Urea buffer and proteins were reduced and alkylated. Equal amount of proteins of different labels were mixed and were digested with trypsin and resulting pe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-01 | MSV000092564 | MassIVE
TranscriptomicsRNA-seq of livers from female mice treated for eight weeks with the glucagon analogue, NNC9204-0043, compared to female mice treated with PBS (control group)
Chronic glucagon receptor activation with a long-acting glucagon analogue increases amino acid catabolism, and to dissect the molecular mechanism underlying this effect, RNA sequencing of liver biopsies from female mice treated for eight weeks with GCGA or PBS were performed.
ORGANISM(S): Mus musculus 
2022-10-11 | E-MTAB-12040 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of the overexpression of the Fil1 transcription factor in S. pombe
The Fil1 transcription factor regulates the response to amino acid starvation. Here we analyse the effects of overexpressing the fil1 coding sequence and of its deregulated expression. The following strains were used: 1] Strains expressing the fil1 gene under the control of the thiamine-repressib...
ORGANISM(S): Schizosaccharomyces pombe 
2018-02-01 | E-MTAB-6226 | biostudies-arrayexpress
ProteomicsAlanine scan of 11 amino acid long novel linear epitope from C. jejuni cj0669 protein
A short sequence of 11 amino acids belonging to the cj0669 protein from Campylobacter jejuni NCTC 11168, which was previously identified as potentially immunogenic, was analyzed via alanine scanning to narrow down the significant amino acid residues within the sequence. Twelve peptides, one represen...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2013-04-06 | E-GEOD-45556 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human HepG2/C3A cells cultured in complete or leucine-devoid medium
HepG2/C3A cells cultured for 42 h in complete or leucine-devoid medium Experiment Overall Design: Total of 6 Samples (Leu vs noLeu)
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-13142 | biostudies-arrayexpress
ProteomicsAlanine scan of 11 amino acid long novel linear epitope from C.jejuni cj0669 protein [2]
A short sequence of 11 amino acids belonging to the cj0669 protein from Campylobacter jejuni NCTC 11168 which was previously identified as potentially immunogenig was analyzed via alanine scanning to narrow down the significant amino acid residues within the sequence. Twelve peptides, one representi...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2013-05-06 | E-GEOD-46651 | biostudies-arrayexpress
TranscriptomicsAlteration of gene expression in MCF-7 cells induced by king cobra venom L-amino acid oxidase (OH-LAAO)
Alteration of gene expression in MCF-7 cells using array-based whole genome gene expression technology . Results provide useful information on the molecular events leading to cell death induced by L-amino acid oxidase enzyme. MCF-7 cells were treated with IC20 value of OH-LAAO or PBS (control). Trea...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-59382 | biostudies-arrayexpress
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