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Dendritic cells (DCs) are central regulators of antitumor T cell immunity and are highly sensitive to metabolic cues. However, the therapeutic potential of targeting DC metabolism remains underexplored. Here, we report upregulation of the creatine transporter (CrT; Slc6a8) in intratumora...

2026-03-11 | MTBLS12797 | MetaboLights
Lipid transfer proteins (LTPs) shuttle their cargo lipids between cellular membranes. LTPs facilitate the costly extraction of a lipid from a donor membrane, and its delivery into the acceptor membrane, but the mechanisms remain poorly understood. We combined extensive molecular dynamics simulations...
2026-10-06 | MTBLS15933 | MetaboLights
PII signal transduction proteins are widely spread among all domains of life where they regulate a multitude of carbon and nitrogen metabolism related processes. Non-diazotrophic cyanobacteria can utilize a high variety of organic and inorganic nitrogen sources. In recent years, several physiologica...
ORGANISM(S): Synechocystis sp. PCC 6803 
2019-07-10 | PXD013411 | Pride
Plants aquire nitrogen from the soil, most commonly in the form of either nitrate or ammonium. Unlike ammonium, nitrate must be reduced (with NADH and ferredoxin as electron donors) prior to assimilation. Thus, nitrate nutrition imposes a substantially greater energetic cost than ammonium nutrition....
ORGANISM(S): Arabidopsis thaliana 
The actinobacteria Frankia alni is able to induce the formation of nodules on the root of a large spectrum of actinorhizal plants, where it converts dinitrogen to ammonia in exchange for plant photosynthates. In the present study, transcriptional analyses were performed on nitrogen-replete free-livi...
ORGANISM(S): Frankia alni ACN14a 
Colletotrichum coccodes secretes ammonium during germination and colonization of host tissue as a mechanism for dual activation of fungal pathogenicity factors and plant cell death via activation of host NADPH oxidase. Ammonium accumulation during colonization of tomato fruits by C. coccodes induced...
ORGANISM(S): Solanum lycopersicum 
Rice seedlings grown on a hydroponic set-up depleted of nitrogen were supplemented with 5mM of nitrate, 5mM of ammonium, 2.5mM of ammonium-nitrate or with a negative control (potassium nitrate). Samples were harvested immediately after treatment and over an 8 points time-course up to 48h after treat...
ORGANISM(S): Oryza sativa Japonica Group 
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