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TranscriptomicsGlobal gene profiling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced neuronal death
AMPA receptors are involved not only in neuronal plasticity but also in excitotoxicity, mediated largely by the influx of Ca2+ (Choi et al., 1988). Their implication has been highlighted in animal models of ischemia and epilepsy. Studies of ischemic rodent models featured that prior to cell death, h...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-22993 | biostudies-arrayexpress
ModelsDutta-Roy2015 - Opening of the multiple AMPA receptor conductance states
Dutta-Roy2015 - Opening of the multiple AMPA receptor conductance states This model is described in the article: Ligand-dependent opening of the multiple AMPA receptor conductance States: a concerted model. Dutta-Roy R, Rosenmund C, Edelstein SJ, Le Novère N. PLoS ONE 2015...
2024-09-02 | BIOMD0000000569 | BioModels
TranscriptomicsIndividual susceptibility to chronic stress is modulated by AMPA receptor function
Chronic stress is a key risk factor for a variety of diseases, but the determinants of individual stress susceptibility are still unclear. Using a recently developed paradigm for chronic social stress in mice we identified animals that were resistant or susceptible to the persistent effects of chron...
ORGANISM(S): Mus musculus 
2010-10-25 | E-GEOD-11211 | biostudies-arrayexpress
GenomicsNon-canonical AMPA receptor blockade reduces lymph node egress and neuroinflammation [scRNA-seq]
Non-canonical AMPA receptor blockade reduces lymph node egress and neuroinflammation [scRNA-seq]
PRJNA1048531 | ENA
ProteomicsSorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2
The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To provide a broader view of SNX27-associated pathologies we performed proteomics in rat primary neurons to ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-28 | PXD026289 | Pride
Membrane trafficking Snx27 Lrfn2 Ampa receptors 
GenomicsNon-canonical AMPA receptor blockade reduces lymph node egress and neuroinflammation [Bulk RNA-seq]
Non-canonical AMPA receptor blockade reduces lymph node egress and neuroinflammation [Bulk RNA-seq]
PRJNA1048526 | ENA
ProteomicsAMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability
AMPA-type glutamate receptors (AMPARs), key elements in excitatory neuro-transmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the en...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-17 | PXD006413 | Pride
Excitatory synaptic transmission Proteomic analysis Intellectual disability Ampa-receptor biogenesis complexes 
GenomicsNBQX AMPA receptor antagonist in vitro treatment of human smooth muscle cells
NBQX disodium salt, an AMPA receptor antagonist, is used for an in vitro treatment of human smooth muscle cells
PRJEB43287 | ENA
UnknownC-terminal domains of transmembrane alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor regulatory proteins not only facilitate trafficking but are major modulators of AMPA receptor function.
Not available
S-EPMC2781656 | biostudies-literature
TranscriptomicsIndividual Stress Vulnerability Is Predicted by Short-Term Memory and AMPA Receptor Subunit Ratio in the Hippocampus
Chronic stress is a key risk factor for a variety of diseases, but the determinants of individual stress susceptibility are still unclear. Using a recently developed paradigm for chronic social stress in mice we identified animals that were resistant or susceptible to the persistent effects of chron...
ORGANISM(S): Mus musculus 
2010-10-25 | GSE11211 | GEO
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