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ProteomicsTargeted LC−MS/MS Reveals Similar Contents of α‑Amylase/ Trypsin-Inhibitors as Putative Triggers of Nonceliac Gluten Sensitivity in All Wheat Species except Einkorn
Amylase/trypsin-inhibitors (ATIs) are putative triggers of nonceliac gluten sensitivity, but contents of ATIs in different wheat species were not available. Therefore, the predominant ATIs 0.19 + 0.53, 0.28, CM2, CM3, and CM16 in eight cultivars each of common wheat, durum wheat, spelt, emmer, and e...
ORGANISM(S): Triticum aestivum (Wheat) 
2019-02-22 | PXD012822 | Pride
Stable isotope dilution assay Modern and ancient wheats Mass spectrometry Α-amylase/trypsin-inhibitor Nonceliac gluten sensitivity 
ProteomicsBreeding from 1891 to 2010 did not increase the content of amylase/trypsin-inhibitors in wheat (Triticum aestivum L.)
The prevalence of hypersensitivities towards wheat has increased in the last decades. Apart from celiac disease these include allergic and other inflammatory reactions summarized under the term non-celiac wheat sensitivity. One suspected trigger is the family of amylase/trypsin-inhibitors (ATIs), no...
ORGANISM(S): Triticum Aestivum 
2023-09-01 | PXD043968 | panorama
ProteomicsQuantitation of ten barley-specific amylase/trypsin-inhibitors in the Global EcoSeed panel
Amylase/trypsin-inhibitors (ATIs) are known allergens and triggers of non-celiac wheat sensitivity. Until now, ATIs were only quantitated in wheat species. We developed and validated a targeted stable isotope dilution analysis LC-MS/MS method to quantitate ten barley-specific ATIs, including one mon...
ORGANISM(S): Hordeum Vulgare 
2026-03-05 | PXD065710 | panorama
ProteomicsComparative quantitative LC-MS/MS analysis of 13 amylase/trypsin inhibitors in ancient and modern Triticum species
Amylase/trypsin inhibitors (ATIs) are major wheat allergens and they are also implicated in causing non-celiac gluten sensitivity and worsening other inflammatory conditions. With only few studies on ATI contents in different Triticum species available so far, we developed a targeted liquid chromato...
ORGANISM(S): Triticum 
2021-03-12 | PXD020714 | panorama
UnknownThe Genetic Factors Controlling the Accumulation of Amylase/Trypsin Inhibitors (ATIs) in Barley for Enhancing Human Nutrition and Health.
Not available
S-EPMC12789939 | biostudies-literature
ProteomicsQuantitation of ATIs in Wheat by LC-MS/MS – iTRAQ
A selection of ATIs was silenced in the common wheat cultivar Bobwhite and durum wheat cultivar Svevo by RNAi and gene editing, respectively, in order to reduce the amounts of ATIs. The controls and silenced lines were analyzed after digestion to peptides by LC-MS/MS with different approaches to eva...
ORGANISM(S): Triticum aestivum (Wheat) Triticum durum 
2022-10-13 | PXD034478 | Pride
Amylase/trypsin inhibitor  wheat  crsipr-cas9  rnai 
ProteomicsQuantification of ATIs in Wheat by LC-MS/MS – LFQ DIA QTOF
A selection of ATIs was silenced in the common wheat cultivar Bobwhite and durum wheat cultivar Svevo by RNAi and gene editing, respectively, in order to reduce the amounts of ATIs. The controls and silenced lines were analyzed after digestion to peptides by LC-MS/MS with different approaches to eva...
ORGANISM(S): Triticum aestivum (Wheat) 
2022-10-13 | PXD034509 | Pride
Amylase/trypsin inhibitor  wheat  crsipr-cas9  rnai 
UnknownComprehensive Characterization and Relative Quantification of α-Amylase/Trypsin Inhibitors from Wheat Cultivars by Targeted HPLC-MS/MS.
Not available
S-EPMC7600490 | biostudies-literature
UnknownDietary Wheat Amylase Trypsin Inhibitors Impact Alzheimer's Disease Pathology in 5xFAD Model Mice.
Not available
S-EPMC7503408 | biostudies-literature
UnknownRelative Abundance of Alpha-Amylase/Trypsin Inhibitors in Selected Sorghum Cultivars.
Not available
S-EPMC7774315 | biostudies-literature
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