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TranscriptomicsRNA-Seq profiling of human embryonic stem cells carrying different levels of mtDNA heteroplasmy cultured in mTeSR Plus and E8 media.
Mitochondrial DNA mutations in components of the electron transport chain disrupt mitochondrial activity and can alter how cells take up and utilize nutrients. To investigate how mtND6 (Complex I) mutations reshape the transcriptional profile of human pluripotent stem cells, we performed bulk RNA se...
ORGANISM(S): Homo sapiens 
2026-06-06 | E-MTAB-17070 | biostudies-arrayexpress
UnknownIncorporating Adaptive Survey Design in a Two-Stage National Web or Mail Mixed-Mode Survey: An Experiment in the American Family Health Study.
Not available
S-EPMC11189656 | biostudies-literature
MetabolomicsMitochondrial Transplantation Ameliorates Doxorubicin-Induced Cardiac Dysfunction via Activating Glutamine Metabolism
Doxorubicin is a wildly used effective anticancer agent. However, doxorubicin use is also related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to be one of the pathogeneses of doxorubicin-induced myocardial injury. In this study, we test the hypothesis that mitoch...
2025-03-13 | MTBLS7989 | MetaboLights
ProteomicsHBS1L-deficient retinal proteomics analysis revealing critical role of ribosomal rescue factor in the photoreceptor cell development
Inherited retinal diseases (IRDs) encompass a genetically diverse group of conditions in which mutations in genes critical to retinal function lead to progressive loss of photoreceptor cells and subsequent visual impairment. A handful of ribosome-associated genes have been implicated in retinal diso...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-25 | PXD045660 | Pride
Hbs1l Retinal degeneration Ribosomal rescue 
UnknownDiphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.
Not available
S-EPMC11053169 | biostudies-literature
UnknownA benchmark of expert-level academic questions to assess AI capabilities.
Not available
S-EPMC12851929 | biostudies-literature
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