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Brown adipocyte-specific ChREBP knockout were generated by crossing mice with a floxed exon1a in the Mlxipl gene with Ucp1-Cre mice. These ChREBPflox/flox Ucp1-Cre+ (Cre+) mice and ChREBP-expressing control (Cre-) mice were studied under various conditions of BAT activation. Housing at room temperat...
ORGANISM(S): Mus musculus 

Detection of biomarkers was extremely important for the early diagnosis, prognosis and therapy optimization of diseases. The purpose of this study was to investigate the differences in serum metabolites between patients with heart failure (HF) and healthy controls (HC), and to diagnose HF qualita...

2025-07-18 | MTBLS9586 | MetaboLights
The experiment aims to identify genes encoding enzymes involved in the biosynthesis of triterpenoid saponins in Saponaria officinalis. RNA-seq data generated were generated from leaves, stems, and roots from 3 months old- hydroponically grown S. officinalis plants that were treated with 50 µM methyl...
ORGANISM(S): Saponaria officinalis 
Osteosarcoma (OS) responds poorly to immune-checkpoint blockade (ICB), and the molecular drivers of its immune-cold state remain unclear. Using multi-omics analyses, we identified an immune-cold OS subtype characterized by enrichment of protein SUMOylation and found the SUMO E1 subunit UBA2 as a key...
ORGANISM(S): Homo Sapiens 
2026-01-28 | PXD073700 |

Gallstones are crystalline deposits in the gallbladder that are traditionally classified as cholesterol, pigment or mixed stones based on their composition. Microbiota and host metabolism variances among the different types of gallstones remain largely unclear. Here, the bile and gallstone microb...

2024-03-11 | MTBLS7736 | MetaboLights
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