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TranscriptomicsMouse colon expression in wild type and STAT5b deficient mice
Regulation of epithelial barrier function is dependent upon precise control of cell survival and activation of inflammatory pathways in response to the enteric flora. These experiments tested differential colon gene expression relative to these pathways in wild type and STAT5b deficient mice. Keywor...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-8942 | biostudies-arrayexpress
TranscriptomicsPlasma miRNA profile as a predictor for early virological response of interferon treatment in chronic hepatitis B patients
To find novel circulating markers associated with prognosis of interferon therapy,We performed microarray analysis of plasma samples in 94 chronic hepatitis B patients Ninety four HBV patients, who underwent PEG-IFN or conventional interferon treatment were enrolled. Their plasma samples before trea...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-29911 | biostudies-arrayexpress
GenomicsGenome-wide analysis of GATA1, GATA2, RUNX1, FLI1 and SCL binding in primary human megakaryocytes
We have mapped the binding sites for the five key regulators GATA1, GATA2, RUNX1, FLI1 and TAL1/SCL in primary human megakaryocytes. Statistical analysis identified subsets of enriched as well as depleted combinatorial binding patterns. In particular simultaneous binding by all 5 factors was highly ...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24674 | biostudies-arrayexpress
ProteomicsAutomated MagNet Enrichment Unlocks Deep and Cost-Effective LC-MS Plasma Proteomics
Plasma is an ideal material for proteomics due to its diverse protein content reflecting physiological and pathological states, and its compatibility with minimally invasive sampling. Deep proteomic profiling of plasma is limited by high-abundant proteins that mask the detection of low-abundant prot...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-05-05 | MSV000097796 | MassIVE
ProteomicsThe changes of Proteomeand Protein Phosphorylation reveals the protective roles of exogenous nitrogen in alleviating cadmium toxicityin poplar plants
Phytoremediation soil polluted by heavy metal has been drawn on a worldwide attention from human society. However, how to improve the efficiency of plant remediation of soil contaminated by cadmium remains unknown. Previous studies showed that nitrogen (N) significantly enhanced cadmium uptake in po...
ORGANISM(S): Populus yunnanensis 
2020-05-26 | PXD013360 | Pride
Plants Exogenous nitrogen Phosphorylation 
ProteomicsComparative proteomic analysis provides novel insights into the complex responses to Pseudoperonospora cubensis infection of cucumber (Cucumis sativus L.)
Cucumber (Cucumis sativus L.) is an economically important vegetable crop distributed in over 80 countries. Downy mildew (DM) caused by the obligate oomycete Pseudoperonospora cubensis is especially destructive in cucumber production. So far, few studies on the changes in proteomes during the P. cub...
ORGANISM(S): Cucumis sativus 
2019-11-12 | PXD010844 | Pride
Downy mildew Cucumber Terpenoid backbone biosynthesis Pathogen resistance Differential accumulated protein Pseudoperonospora cubensis 
ProteomicsLabel-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line
Hepatitis B virus (HBV) infection is a major health problem worldwide. Recent evidence suggests that various viruses can manipulate the infection process by secretion of specific viral and cellular components into exosomes, small nanometer-sized (30-150 nm) vesicles secreted from various cells. Howe...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080718 | MassIVE
ProteomicsLoss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella
Aberrant sperm flagella impair sperm motility and cause male infertility, yet the genes which have been identified in multiple morphological abnormalities of the flagella (MMAF) can only explain the pathogenic mechanisms of MMAF in a small number of cases. Here, we identify and functionally characte...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD011730 | Pride
Mutation Sperm flagella Morphological abnormalities Proteomics analysis 
GenomicsCombinatorial Transcriptional Control in Blood Stem/Progenitor Cells: Genome-wide Analysis of 10 major Transcriptional Regulators
Combinatorial transcription factor (TF) interactions control cellular phenotypes and therefore underpin stem cell formation, maintenance and differentiation. Here we report the genome-wide binding patterns and combinatorial interactions for 10 key regulators of blood stem/progenitor cells (Scl/Tal1,...
ORGANISM(S): Mus musculus 
2010-10-07 | E-GEOD-22178 | biostudies-arrayexpress
ProteomicsA new identified suppressor of Cdc7p/SepH kinase, PomA, regulates fungal asexual reproduction via affecting phosphorylation of MAPK-HogA
The septation initiation network (SIN), composed of a conserved SepH (Cdc7p) kinase cascade, plays an essential role in fungal cytokinesis/septation and conidiation for asexual reproduction, while the mitogen-activated protein kinase (MAPK) pathway depends on successive signaling cascade phosphoryla...
ORGANISM(S): Emericella nidulans (Aspergillus nidulans) 
2019-06-17 | PXD012514 | Pride
The septation initiation network (sin) Aspergillus nidulans The mitogen-activated protein kinase (mapk) Poma 
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