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MetabolomicsA Transferable Workflow for Confident Annotation of Polar Analytes in 4D-Metabolomics
Introduction High-confidence annotation of polar metabolites remains a central challenge in non-targeted metabolomics. While derivatization improves chromatographic retention and ionization of derivatized compounds, it changes the molecules, making annotation using conventional annotation workflows ...
2026-10-19 | MTBLS16057 | MetaboLights
MetabolomicsMulti-omics analysis of thermogenic lipolysis in brown adipocytes

The integration of omics technologies into molecular biological research has transformed it into a field where a system can be investigated as a whole by combining information from multiple biochemical layers. This extension of traditional molecular biology, where various data sources are conside...

2025-11-12 | MTBLS12307 | MetaboLights
MetabolomicsIn silico derivatization and CCS value prediction improve interoperable semi-untargeted stable-isotope labeling analysis

Chemical derivatization can improve the detectability of analytically challenging compounds, but untargeted feature identification and annotation for chemically derivatized samples are limited by the availability of reference spectra. With the workflow presented in this manuscript, challenges ass...

2026-10-20 | MTBLS14808 | MetaboLights
MetabolomicsRapid chromatography combined with trapped ion mobility mass spectrometry for analysis of derivatized small molecules
Liquid chromatography (LC) separates biomolecules based on their physicochemical properties. Reproducible retention times support compound identification, while efficient separation of structurally similar compounds is essential for accurate quantification. However, conventional LC methods are often...
2026-06-30 | MTBLS14813 | MetaboLights
MetabolomicsMulti-omics characterization of acquired Olaparib resistance in BRCA1 and BRCA2 mutant breast cancer cell lines
Poly (ADP-ribose) polymerase inhibitors (PARPi) are widely used as targeted therapies against breast cancers with BRCA mutations. However, the development of resistance to PARPi poses a significant challenge for long-term efficacy of these therapies, warranting further understanding of mechanisms of...
2026-05-11 | MTBLS12109 | MetaboLights
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