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MetabolomicsSeawater Analysis by Ambient Mass Spectrometry-Based Seaomics

A transmission mode-direct analysis in real time-quadrupole time of flight-mass spectrometry (TM-DART-QTOF-MS)-based analytical method coupled to multivariate statistical analysis was developed to interrogate lipophilic compounds in seawater samples without the need of desalin...

2020-05-19 | MTBLS1198 | MetaboLights
MetabolomicsTranscriptomic and metabolomic analysis of liver cirrhosis
Liver cirrhosis is one of the leading causes of decreased life expectancy worldwide. However, the molecular mechanisms underlying the development of liver cirrhosis remain unclear. In this study, we performed a comprehensive analysis using transcriptome and metabolome sequencing to explore the genes...
2024-08-07 | MTBLS5665 | MetaboLights
MetabolomicsDetection and Analysis of Rhizosphere Metabolites
To evaluate whether maternal nitrogen histories influenced the rhizosphere metabolite profiles of offspring plants under contrasting soil N availability, seeds from different nitrogen-history maternal lineages were sown into soils established under either N0 (no additional N input) or N2 (2 g N per ...
2026-05-18 | MTBLS14515 | MetaboLights
MetabolomicsMonitoring of system conditioning after blank injections in untargeted UPLC-MS metabolomic analysis
Ultra-performance liquid chromatography - mass spectrometry (UPLC-MS) is widely used for untargeted metabolomics in biomedical research. To optimize the quality and precision of UPLC-MS metabolomic analysis, evaluation of blank samples for the elimination of background features is required. Although...
2022-01-19 | MTBLS906 | MetaboLights
MetabolomicsMetabolomics analysis of antibacterial mechanism
Metabolomics, as a high-throughput analytical technique, enables comprehensive analysis of the metabolic changes in microorganisms under different environmental conditions, revealing the molecular basis of their antibacterial mechanisms. This study employs metabolomics analysis to investigate the an...
2025-04-25 | MTBLS11717 | MetaboLights
MetabolomicsUntargeted LC–MS Metabolomic Analysis of Connexin 43 in Bone Metabolism

MC3T3-E1 cells were divided into two groups: si-NC and si-Connexin43. Cx43 expression was knocked down using siRNA transfection, followed by LC–MS-based untargeted metabolomic analysis to investigate metabolic alterations associated with Connexin 43 deficiency in osteoblasts and its potential rol...

2026-09-29 | MTBLS14532 | MetaboLights
MetabolomicsMetabolomic analysis of riboswitch containing E. coli recombinant expression system
In this study we have employed metabolomics approaches to understand the metabolic effects of producing enhanced green fluorescent protein (eGFP) as a recombinant protein in Escherichia coli cells. This metabolic burden analysis was performed against a number of recombinant expression systems and co...
2017-11-16 | MTBLS393 | MetaboLights
MetabolomicsMetabolomics Analysis of Limoniastrum monopetalum Extract

Limoniastrum monopetalum is a halophytic plant traditionally used in folk medicine for its purported antioxidant, antimicrobial, and anti-inflammatory properties. However, its chemical composition and bioactive constituents remain insufficiently characterized. In this study, we employed an untarg...

2025-08-25 | MTBLS12880 | MetaboLights
Metabolomicswidely targeted metabolomic analysis

Based on widely targeted metabolomic analysis, we explored the differences in metabolite composition and content of tomato fruits with different genotypes or exogenous metabolites were added. In addition, we also investigated the effects of different treatments on the composition and content of b...

2025-12-14 | MTBLS13506 | MetaboLights
MetabolomicsRabbit plasma metabolomic analysis of Nitroproston: a multi target natural prostaglandin based-drug (Untargeted study)
INTRODUCTION: Nitroproston® is a novel multi-target drug bearing natural prostaglandin E2 (PGE2) and nitric oxide (NO)-donating fragments for treatment of inflammatory and obstructive diseases (i.e. asthma and obstructive bronchitis). OBJECTIVES: To investigate the effects of Nitroproston® adm...
2019-08-27 | MTBLS727 | MetaboLights
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