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GenomicsChIP-seq analysis against E2F7 in CAL62 anaplastic thyroid cancer cells
ChIP-seq experiment was performed using an antibody against E2F7 in CAL62 anaplastic thyroid cancer cell line, in order to define the genomic regions bound by this transcription factor and exploit its genomic function in this cancer setting.
ORGANISM(S): Homo sapiens 
2023-02-07 | E-MTAB-12277 | biostudies-arrayexpress
TranscriptomicsRNA-seq of anaplastic thyroid carcinoma cells (CAL62 and 8505c) after E2F7 silencing
Gene expression comparison between anaplastic thyroid carcinoma cells (CAL62 and 8505c) transfected with si-RNA against E2F7 or scramble oligos, with the intent of defining the gene expression program under the control of this transcription factor in this tumor subtype.
ORGANISM(S): Homo sapiens 
2023-02-07 | E-MTAB-9788 | biostudies-arrayexpress
GenomicsTargeted sequencing of anaplastic thyroid cancer genome of Indian origin
The study involves targeted sequencing of 30 orphan FFPE tumors obtained from anaplastic thyroid carcinoma patients of Indian origin. With this, we aim to describe the mutation profile of this specific subset of anaplastic thyroid cancer patients. This knowledge will further allow us to gain an insi...
ORGANISM(S): Homo sapiens 
2025-07-01 | E-MTAB-13774 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome sequencing of anaplastic thyroid cancer of Indian origin
The study involves whole transcriptome sequencing of 30 orphan FFPE tumors obtained from anaplastic thyroid carcinoma patients of Indian origin. With this, we aim to describe the expression profile, fusion genes and pathogen profile of this specific subset of anaplastic thyroid cancer patients. Thi...
ORGANISM(S): Homo sapiens 
2025-11-09 | E-MTAB-12479 | biostudies-arrayexpress
TranscriptomicsWhole exome sequencing of anaplastic thyroid cancer of Indian origin
The study involves whole exome sequencing of 38 orphan primary tumors obtained from anaplastic thyroid carcinoma patients of Indian origin. With this, we aim to describe the mutational profile of this specific subset of anaplastic thyroid cancer patients. This knowledge will further allow us to gai...
ORGANISM(S): Homo sapiens 
2025-07-01 | E-MTAB-13697 | biostudies-arrayexpress
ProteomicsIntegrative Proteogenomic Characterization Reveals Therapeutic Targets in Poorly Differentiated and Anaplastic Thyroid Cancers
In our study, we constructed a multicenter thyroid-cancer cohort consisting of 467 formalin-fixed paraffin-embedded (FFPE) samples, among which WES, proteome, and phosphorylated proteome analysis were conducted. Thyroid tumors consisted of 124 ATC samples, 47 PDTC samples and 177 PTC samples (includ...
ORGANISM(S): Homo Sapiens 
2025-03-16 | PXD054521 |
ProteomicsComparative proteomic profiling of ectosomes derived from thyroid carcinoma and normal thyroid cells uncovers multiple proteins with functional implications in cancer
Proteins carried by tumor-derived ectosomes play an important role in cancer progression and are considered promising diagnostic markers. In the present study a shotgun nanoLC-MS/MS proteomic approach was applied to profile and compare the protein content of ectosomes released in vitro by normal hum...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-17 | MSV000088850 | MassIVE
TranscriptomicsGene expression profiling of human anaplastic thyroid carcinoma cells by microarray
In this study, we profiled the change of gene expression by p53 knock-down on anaplastic thyroid carcinoma (ATC) cell line, KAT-18 cells using Applied Biosystem's Microarrays. When compared with the untreated control KAT-18 cells, 2,926 genes were found to have altered expression levels of 2-fold or...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-12912 | biostudies-arrayexpress
GenomicsWhole genome and transcriptome analysis of anaplastic thyroid carcinoma
Whole genome and transcriptome analysis of anaplastic thyroid carcinoma
EGAS00001001214 | EGA
TranscriptomicsGene array analysis of anaplastic thyroid carcinoma tissue versus matched and unmatched normal thyroid tissue
Currently there is a lack of effective therapies which result in long-term durable response for patients presenting with anaplastic thyroid carcinoma (ATC), a very rare and lethal variant of thyroid cancer. ATC is resistant to chemotherapy, radiation, and targeted therapies currently available. In a...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-65144 | biostudies-arrayexpress
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