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MetabolomicsHyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells
Premature infants require oxygen supplementation to survive, but excess oxygen causes retinovascular growth suppression that underlies the leading cause of infant blindness known as retinopathy of prematurity (ROP). We analyzed changes in intermediary metabolism during hyperoxia in human retinal end...
2020-03-12 | MTBLS1228 | MetaboLights
GenomicsPyruvate Anaplerosis is a Targetable Vulnerability in Persistent Leukaemic Stem Cells
Pyruvate Anaplerosis is a Targetable Vulnerability in Persistent Leukaemic Stem Cells
PRJNA895475 | ENA
TranscriptomicsPyruvate Anaplerosis is a Targetable Vulnerability in Persistent Leukaemic Stem Cells
Deregulated oxidative metabolism is a hallmark of leukaemia. While use of tyrosine kinase inhibitors (TKIs) such as imatinib has led to increased survival of chronic myeloid leukaemia (CML) patients, it fails to eradicate disease initiating leukemic stem cells (LSCs). Whether TKI-treated CML LSCs re...
ORGANISM(S): Homo sapiens 
2023-06-27 | GSE216837 | GEO
UnknownPyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells.
Not available
S-EPMC10435520 | biostudies-literature
UnknownEnvironmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition.
Not available
S-EPMC5589418 | biostudies-literature
UnknownEnhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition.
Not available
S-EPMC4967856 | biostudies-literature
UnknownNDRG2 inhibits pyruvate carboxylase-mediated anaplerosis and combines with glutamine blockade to inhibit the proliferation of glioma cells.
Not available
S-EPMC9442009 | biostudies-literature
UnknownImpaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma.
Not available
S-EPMC8228515 | biostudies-literature
UnknownInhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension.
Not available
S-EPMC7074087 | biostudies-literature
ProteomicsSystems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism
submission for the paper "Systems level profiling of arginine starvation in ASS1 negative sarcomas reveals ERK and MYC adaptive metabolic reprogramming of TCA anaplerosis and lipid metabolism"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-09 | MSV000084785 | MassIVE
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