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TranscriptomicsEnergy Metabolism during Anchorage-Independence
The detachment of epithelial cells, but not cancer cells, causes anoikis due to reduced energy production. Invasive tumor cells generate three splice variants of the metastasis gene osteopontin. The cancer-specific form osteopontin-c supports anchorage-independence through inducing oxidoreductases a...
ORGANISM(S): Homo sapiens 
2014-02-21 | E-GEOD-55193 | biostudies-arrayexpress
TranscriptomicsExpression data from breast cancer cell lines with various colony-forming ability
Cultured cancer cells exhibit substantial phenotypic heterogeneity when measured in a variety of ways such as sensitivity to drugs or the capacity to grow under various conditions. Among these, the ability to exhibit anchorage-independent cell growth (colony forming capacity in semisolid media), ha...
ORGANISM(S): Homo sapiens 
2009-04-10 | E-GEOD-15026 | biostudies-arrayexpress
TranscriptomicsGenome functional screening identifies GAB2 as a key promoter of anchorage independence in normal and neoplastic cells
Acquisition of independence from anchorage to the extracellular matrix is a critical event for onset and progression of solid cancers. To identify and characterize new genes conferring anchorage independence, we transduced MCF10A human normal breast cells with a retroviral cDNA expression library an...
ORGANISM(S): Homo sapiens Mus musculus 
2009-10-21 | GSE18237 | GEO
GenomicsAberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence [miR-Agilent]
Cervical cancer and a subset of anogenital and head-and-neck carcinomas are caused by persistent infection with high-risk types of the human papillomavirus (hrHPV). Early stages of hrHPV-induced carcinogenesis can be faithfully mimicked in vitro. A major hallmark of hrHPV-transformed cells is their ...
ORGANISM(S): Homo sapiens 
2017-02-09 | GSE78278 | GEO
Methylation profilingAberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence [methylation-Illumina]
Cervical cancer and a subset of anogenital and head-and-neck carcinomas are caused by persistent infection with high-risk types of the human papillomavirus (hrHPV). Early stages of hrHPV-induced carcinogenesis can be faithfully mimicked in vitro. A major hallmark of hrHPV-transformed cells is their ...
ORGANISM(S): Homo sapiens 
2017-02-09 | GSE78277 | GEO
TranscriptomicsEnergy Metabolism during Anchorage-Independence
The detachment of epithelial cells, but not cancer cells, causes anoikis due to reduced energy production. Invasive tumor cells generate three splice variants of the metastasis gene osteopontin. The cancer-specific form osteopontin-c supports anchorage-independence through inducing oxidoreductases a...
ORGANISM(S): Homo sapiens 
2014-02-21 | GSE55193 | GEO
UnknownHuR-dependent SOD2 protein synthesis is an early adaptation to anchorage-independence.
Not available
S-EPMC9121325 | biostudies-literature
GenomicsAberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence
Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence
PRJNA313079 | ENA
UnknownHematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells.
Not available
S-EPMC9433100 | biostudies-literature
UnknownAberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence.
Not available
S-EPMC5190061 | biostudies-literature
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