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TranscriptomicsTranscription profiling of human CD16+ and CD16- peripheral blood monocytes from healthy individuals
Human peripheral blood monocytes (Mo) consist of subsets distinguished by expression of CD16 (FCGRIII) and chemokine receptors. Classical CD16- Mo express CCR2 and migrate in response to CCL2, while a minor CD16+ Mo subset expresses CX3CR1 and migrates into tissues expressing CX3CL1. CD16+ Mo produc...
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-16836 | biostudies-arrayexpress
TranscriptomicsCharacterisation of Two New Th17-Subsets with Distinct Contribution to HIV-1 Persistence under Antiretroviral Therapy
Th17 cells act as the first line of defense against pathogens at mucosal surfaces. Their paucity during HIV infection causes disease progression. Here, we reveal the existence of two new CCR6+CD161+ subsets, CCR4-CXCR3- (DN; double negative) and CCR4+CXCR3+ (DP; double positive), expressing typical ...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-66972 | biostudies-arrayexpress
TranscriptomicsExpression data from human Th1 and Th1Th17 cells
We previously demonstrated that Th1Th17 cells are highly permissive to HIV-1, whereas Th1 cells are relatively resistant. Here, we investigated molecular mechanisms underlying these differences. Superior HIV replication in Th1Th17 vs. Th1 cells was regulated by entry and post-entry mechanisms. We us...
ORGANISM(S): Homo sapiens 
2013-08-26 | E-GEOD-50175 | biostudies-arrayexpress
TranscriptomicsMolecular mechanisms of HIV-1 permissiveness in CCR4+CCR6+ Th17 cells
We previously reported that CCR4+CCR6+Th17 cells are permissive to HIV, while CXCR3+CCR6- Th1 cells are relatively resistant. To identify molecular mechanisms underlying these differences, we performed a genome-wide transcriptional profiling in CXCR3+CCR6-Th1, CCR4+CCR6-Th2, CCR4+CCR6+Th17, and CXCR...
ORGANISM(S): Homo sapiens 
2015-08-30 | E-GEOD-70396 | biostudies-arrayexpress
TranscriptomicsProinflammatory isoforms of IL-32 as novel and robust biomarkers for control failure in HIV-infected slow-progressors.
HIV-infected slow-progressors (SP) represent a heterogeneous group of subjects who spontaneously control HIV infection without treatment for several years while showing moderate signs of disease progression. Here we determined the frequency of SP subjects who showed loss of HIV control within our Ca...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-74790 | biostudies-arrayexpress
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