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Transient abnormal myelopoiesis (TAM) is a clonal pre-leukemic disorder that progresses to myeloid leukemia of Down syndrome (ML-DS) through the accumulation of genetic alterations. To investigate the mechanism of leukemogenesis in this disorder, a xenograft model of TAM was established using NOD/Sh...
ORGANISM(S): Homo sapiens 
Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where pluripotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells....
ORGANISM(S): Homo sapiens 
Autophagy mediates p53 degradation and is essential for human myelopoiesis
Myc Driven Emergency Myelopoiesis Reprograms HPSC Metabolism
Mature B cells and Mesenchymal Stem Cells control emergency myelopoiesis
Systemic Inflammation Impairs Human Myelopoiesis [bulkRNA-Seq]
Systemic Inflammation Impairs Human Myelopoiesis [scRNA-Seq]
Cartography of emergency myelopoiesis identifies dysregulated metabolism
Introduction Immune checkpoint blockade (ICB) immunotherapy has revolutionized cancer treatment, demonstrating exceptional clinical responses in a wide range of cancers. Despite the success, a significant proportion of patients still fail to respond, highlighting the existence of unappreciated mecha...
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