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GenomicsGenome-wide binding of WDR5 and GRHL3
The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show...
ORGANISM(S): Homo sapiens 
2012-11-10 | E-GEOD-42180 | biostudies-arrayexpress
GenomicsGrhl3 is essential for epidermal barrier repair from both physical and immune injury, relevance to lesional skin disease
Epidermal barrier repair mechanisms activated in psoriasis lesions are likely involved in limiting the severity of this disease. We show that loss of grainyhead-like 3 (Grhl3), a pro-terminal differentiation factor in the epidermis, is sufficient to trigger greater sensitivity to and delayed resolut...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-52648 | biostudies-arrayexpress
TranscriptomicsAnalysis of gene expression in differentiated human primary keratinocytes depleted for Grainyhead like 3 (GRHL3)
Human primary keratinocytes were depleted of GRHL3 by siRNA and induced to differentiated for 2 days by addition of Calcium Primary normal human keratinocytes were transfected with GRHL3 or scrambled control siRNA using RNAi max (Life Technologies). 24 hours post transfection medium was raised to 1....
ORGANISM(S): Homo sapiens 
2012-07-18 | E-GEOD-37049 | biostudies-arrayexpress
UnknownCharacterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation.
Not available
S-EPMC5704477 | biostudies-literature
UnknownCircadian control of interferon-sensitive gene expression in murine skin.
Not available
S-EPMC7084068 | biostudies-literature
TranscriptomicsBmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis
This SuperSeries is composed of the following subset Series: GSE38622: Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [telogen]. GSE38623: Bmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epider...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-38625 | biostudies-arrayexpress
UnknowntauFisher predicts circadian time from a single sample of bulk and single-cell pseudobulk transcriptomic data.
Not available
S-EPMC11076472 | biostudies-literature
UnknownCofactors of LIM Domains Associate with Estrogen Receptor α to Regulate the Expression of Noncoding RNA H19 and Corneal Epithelial Progenitor Cell Function.
Not available
S-EPMC4933239 | biostudies-literature
TranscriptomicsBmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [telogen].
While several physiological skin parameters vary in a circadian manner, the identity of genes participating in chronobiology of skin remains unknown, leading us to define the circadian transcriptome of mouse skin at two different stages of the hair cycle, telogen and anagen. The circadian transcrip...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-38622 | biostudies-arrayexpress
TranscriptomicsBmal1 controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis [Bmal1 KO]
While several physiological skin parameters vary in a circadian manner, the identity of genes participating in chronobiology of skin remains unknown, leading us to define the circadian transcriptome of mouse skin at two different stages of the hair cycle, telogen and anagen. The circadian transcrip...
ORGANISM(S): Mus musculus 
2012-08-01 | E-GEOD-38624 | biostudies-arrayexpress
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