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TranscriptomicsIdentifying transcription start sites and active enhancer elements using BruUV-seq
BruUV-seq utilizes UV light to introduce transcription-blocking DNA lesions randomly in the genome prior to bromouridine-labeling and deep sequencing of nascent RNA. By inhibiting transcription elongation, but not initiation, pre-treatment with UV light leads to a redistribution of transcription rea...
ORGANISM(S): Homo sapiens 
2015-12-21 | E-GEOD-75398 | biostudies-arrayexpress
GenomicLung Cancer Susceptibility in Smokers

Over 85% of all patients diagnosed with lung cancer report a history of tobacco use, though only 10% of tobacco smokers eventually develop lung cancer. Epidemiologic studies have shown that family members of patients with lung cancer have a higher risk of developing lung cancer than controls. In ...

phs000728 | dbGaP
TranscriptomicsGenome-Wide Transcriptional Effects of the Anti-Cancer Agent Camptothecin
The anti-cancer drug camptothecin inhibits replication and transcription by trapping DNA topoisomerase I (Top1) covalently to DNA in a M-bM-^@M-^\cleavable complexM-bM-^@M-^]. To examine the effects of camptothecin on RNA synthesis genome-wide we used Bru-Seq and show that camptothecin treatment aff...
ORGANISM(S): Homo sapiens 
2013-10-29 | E-GEOD-48678 | biostudies-arrayexpress
UnknownHaplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1.
Not available
S-EPMC2846106 | biostudies-literature
UnknownGenome-wide association study of familial lung cancer.
Not available
S-EPMC6148967 | biostudies-literature
UnknownRisk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
Not available
S-EPMC2714722 | biostudies-literature
UnknownFine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.
Not available
S-EPMC2746091 | biostudies-literature
UnknownRare deleterious germline variants and risk of lung cancer.
Not available
S-EPMC7887261 | biostudies-literature
UnknownNew loci associated with kidney function and chronic kidney disease.
Not available
S-EPMC2997674 | biostudies-literature
UnknownA System for Phenotype Harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Program.
Not available
S-EPMC8485147 | biostudies-literature
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