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TranscriptomicsRNA-seq of human fibroblast cell cultures treated with resveratrol against DMSO treated controls, with and without siRNA treatment targeting SIRT1
Resveratrol (RSV) is a small compound with many reported beneficial effects, including increased expression of genes involved in inborn errors of metabolism. We wanted to investigate the effects of RSV on gene regulation on a global scale in order to detect new target genes for RSV mediated up-regul...
ORGANISM(S): Homo sapiens 
2018-11-12 | E-MTAB-7360 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human cell line HepG2 edited with CRISPR and treated with splice-switching oligo inhibiting a pseudoexon in PCCA against control SSO and control HepG2 cells
Cellular models of propionic acidemia were generated using HepG2 cells that were edited by CRISPR gene editing to introduce the pathogenic PCCA c.1285-1416A>G variant associated with propionic acidemia, and a 7 bp deletion of a predicted hnRNP A1 binding motif (c.1285-1411delTAGAACA), which causes c...
ORGANISM(S): Homo sapiens 
2023-12-10 | E-MTAB-13549 | biostudies-arrayexpress
TranscriptomicsRNA-seq of rat heart myoblast cell line H9c-2 treated with hydroxyurea with and without CK2alpha down-regulation compared to untreated controls.
Treatment of previously established cell-line expressing doxycycline inducible shRNA against CK2alpha (H9c2-CK2alpha-44) with hydroxyurea alone or in combination with doxycycline, and compared against untreated controls, to examine CK2alpha's role on regulation of cell cycle and DNA replication.
ORGANISM(S): Rattus norvegicus 
2023-03-31 | E-MTAB-10752 | biostudies-arrayexpress
UnknownMedium-chain acyl-CoA dehydrogenase (MCAD) mutations identified by MS/MS-based prospective screening of newborns differ from those observed in patients with clinical symptoms: identification and characterization of a new, prevalent mutation that results in mild MCAD deficiency.
Not available
S-EPMC1226127 | biostudies-literature
TranscriptomicshnRNP A1 iCLIP
This experiment identifies hnRNP A1 binding sites transcriptome-wide in Hela cells. HeLa cells with inducible expression of T7-tagged hnRNP A1 were grown to approximately 90% confluence and then subject to iCLIP analysis (following the protocol from Huppertz et al. 2014 (iCLIP: protein-RNA interact...
ORGANISM(S): Homo sapiens 
2016-06-23 | E-MTAB-3612 | biostudies-arrayexpress
TranscriptomicsRNA-seq of CK2alpha-silenced H9-c2 derived myoblasts using siRNA or doxycyclin inducible shRNA.
Using two different approaches to CK2alpha-silencing, we have used RNA-seq to identify variation in gene-expression of important cell cycle regulators with relevance to heart-associated defects.
ORGANISM(S): Rattus norvegicus 
2019-10-09 | E-MTAB-8067 | biostudies-arrayexpress
TranscriptomicsSplicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans
RNA-seq of C.elegans strain N2 (wt) with and without sfa-1 RNAi at adult day 3 and day 15, C. elegans strain DA1116 (eat-2(ad1116)) with and without sfa-1 RNAi at adult day 3, day 15, and day 27, C. elegans strain SS104 (glp-4(bn2)) with and without hrp-2 RNAi at adult day 1, and HeLa cells with and...
ORGANISM(S): Caenorhabditis elegans 
2016-11-29 | E-MTAB-4866 | biostudies-arrayexpress
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