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TranscriptomicsRNA-seq of human cell line HepG2 edited with CRISPR and treated with splice-switching oligo inhibiting a pseudoexon in PCCA against control SSO and control HepG2 cells
Cellular models of propionic acidemia were generated using HepG2 cells that were edited by CRISPR gene editing to introduce the pathogenic PCCA c.1285-1416A>G variant associated with propionic acidemia, and a 7 bp deletion of a predicted hnRNP A1 binding motif (c.1285-1411delTAGAACA), which causes c...
ORGANISM(S): Homo sapiens 
2023-12-10 | E-MTAB-13549 | biostudies-arrayexpress
TranscriptomicsRNA-seq of rat heart myoblast cell line H9c-2 treated with hydroxyurea with and without CK2alpha down-regulation compared to untreated controls.
Treatment of previously established cell-line expressing doxycycline inducible shRNA against CK2alpha (H9c2-CK2alpha-44) with hydroxyurea alone or in combination with doxycycline, and compared against untreated controls, to examine CK2alpha's role on regulation of cell cycle and DNA replication.
ORGANISM(S): Rattus norvegicus 
2023-03-31 | E-MTAB-10752 | biostudies-arrayexpress
TranscriptomicsRNA-seq of spinal cord, brain, liver, and muscle from an SMA mouse model
This study describes RNA-seq results from total spinal cord, brain, liver and muscle samples taken at PND1 and PND5 from an SMA mouse model paired with samples taken from heterozygous litter-mates. There are four mouse in each group.
ORGANISM(S): Mus musculus 
2016-08-25 | E-MTAB-3664 | biostudies-arrayexpress
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