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MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. brucei assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-09-23 | MTBLS1474 | MetaboLights
TranscriptomicsIn vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei
The host range of African trypanosomes is influenced by innate protective molecules in the blood of primates. A subfraction of human high-density lipoprotein (HDL) containing apolipoprotein A-I, apolipoprotein L-I, and haptoglobin-related protein is toxic to Trypanosoma brucei brucei but not the hum...
ORGANISM(S): Trypanosoma brucei brucei 
2007-07-04 | E-GEOD-8369 | biostudies-arrayexpress
GenomicsTrypanosoma brucei brucei
In vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei
PRJNA101397 | ENA
GenomicsRecurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Follicular lymphoma (FL) is an incurable B-cell malignancy characterized by the t(14;18) and mutations in one or more components of the epigenome. Whilst frequent gene mutations in signaling pathways, including JAK-STAT, NOTCH and NF-κB, have also been defined, the spectrum of these mutations typic...
EGAS00001001190 | EGA
UnknownTransformation of follicular lymphoma to diffuse large B-cell lymphoma proceeds by distinct oncogenic mechanisms.
Not available
S-EPMC2532951 | biostudies-literature
Genomicsena-DATASET-BCI-18-03-2015-12:48:54:303-380 - samples
Whole exome sequencing data of 5 patients diagnosed with FL that had undergone several relapse episodes without evidence of transformation
EGAD00001001301 | EGA
GenomicsBarts Cancer Institute - Follicular Lymphoma Whole Genome Sequencing Project Data Access Committee
Data Access Committee EGAC00001000086
EGAC00001000086 | EGA
TranscriptomicsGenotyping of human diagnosic AML samples reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias
Genome-wide analysis of single nucleotide polymorphisms in 64 acute myeloid leukemias has revealed that 20% exhibited large regions of homozygosity that could not be accounted for by visible chromosomal abnormalities in the karyotype. Further analysis confirmed that these patterns were due to partia...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7490 | biostudies-arrayexpress
UnknownEfficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico.
Not available
S-EPMC8693692 | biostudies-literature
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