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G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. We developed a neutralizing monoclonal antibody to the murine G-CSF receptor (G-CSFR), which antagonizes binding of murine G-CSF and inhibits G-CSFR signallin...
ORGANISM(S): Mus musculus 
Hypoxia-inducible factor 1α (HIF-1α) broadly orchestrates metabolic reprogramming in inflammatory macrophages. However, how HIF-1α is activated in the earliest events following pattern recognition receptor activation remains unclear. We found that HIF-1α is functionally active shortly after macroph...
ORGANISM(S): Mus musculus 
Clarke2000 - One-hit model of cell death in neuronal degenerations This one-hit model fits different neuronal-death associated diseases for different animal models.  This model is described in the article: A one-hit model of cell death in inherited neuronal degenerations. Clarke G...
2024-09-02 | BIOMD0000000538 | BioModels
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