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TranscriptomicsTranscription profiling of rat primary cortical neurons exposed to anesthetics
Inhaled anesthetics produce many effects and bind to a large number of brain proteins, but it is not yet clear if this is accompanied by widespread changes in gene expression of the biological targets. Such changes in expression might implicate functionally important targets from the large pool of ...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-2982 | biostudies-arrayexpress
ProteomicsImpact of anesthetics on rat hippocampus and neocortex: a comprehensive proteomic study based on label-free mass spectrometry
In this work, in vivo experiment simulating a general anesthesia and ICU sedation was designed to assess the impact of two intravenous (midazolam, dexmedetomidine) and two inhalational (isoflurane, desflurane) agents to neuronal centers for cognition (neocortex), learning, and memory (hippocampus). ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-23 | PXD045159 | Pride
Hippocampus Neocortex Long-term potentiation Anesthetics Gaba signaling Vdac Apoptosis Nmdar Label-free proteomics 
UnknownAnesthetics or anesthetic techniques and cancer surgical outcomes: a possible link.
Not available
S-EPMC8175878 | biostudies-literature
GenomicsSerum from pediatric patients younger than 4 years old with longer exposure of general anesthetics (>3hrs)
Serum from pediatric patients younger than 4 years old with longer exposure of general anesthetics (>3hrs)
PRJNA1132265 | ENA
GenomicsSerum from pediatric patients younger than 4 years old with longer exposure of general anesthetics (>3hrs)
Pediatric patients detected were younger than 4 years old with longer exposure of general anesthetics (>3hrs) Pediatric patients detected were younger than 4 years old with longer exposure of general anesthetics (>3hrs)
ORGANISM(S): Homo sapiens 
2025-12-30 | GSE271593 | GEO
UnknownLocal anesthetics induce autophagy in young permanent tooth pulp cells.
Not available
S-EPMC4979463 | biostudies-literature
ProteomicsTime-Dependent Effects of Anesthetic Administration on the Rat Hypothalamus and Cerebral Cortex Peptidome
Prohormone-derived neuropeptides act as cell-cell signaling molecules to mediate a wide variety of biological processes in the animal brain. Mass spectrometry-based peptidomic experiments are valuable approaches to gain insight into the dynamics of individual peptides under different physiological c...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-25 | PXD043738 | Pride
Keywords peptidomics Hypothalamus Neuropeptides Anesthetics Cerebral cortex 
GenomicsGeneral Anesthetics Induce Epigenetic Alterations in Germ Cells that Result in Autism-like Behaviors
General Anesthetics Induce Epigenetic Alterations in Germ Cells that Result in Autism-like Behaviors
PRJNA704822 | ENA
ProteomicsShort-term administration of common anesthetics does not dramatically change the endogenous peptide profile in the rat pituitary
To identify and quantify the relative abundances of cell-cell signaling peptides in different physiological states, LC-MS-based peptidomics workflows are commonly utilized on freshly dissected tissue. In such animal experiments, the administration of general anesthetics is an important step for many...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-09-23 | PXD034821 | Pride
Pituitary Anesthesia Rat Peptidomics 
GenomicsGeneral Anesthetics Induce Epigenetic Alterations in Germ Cells that Result in Autism-like Behaviors
One in 54 children in the U.S. is diagnosed with Autism Spectrum Disorder (ASD). However, no one genetic mutation can fully explain the neuropathogenesis of ASD. Given the highly heritable nature of ASD, epigenetic alterations may be the missing link in understanding ASD. Human and animal studies ha...
ORGANISM(S): Mus musculus 
2021-05-20 | GSE167500 | GEO
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