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GenomicsThe C. burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear riboprotein complex for reprogramming host cell transcription
The C. burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear riboprotein complex for reprogramming host cell transcription
PRJNA769091 | ENA
TranscriptomicsThe C. burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear riboprotein complex for reprogramming host cell transcription
In this study, we analyzed the molecular activity of the anti-apoptotic T4SS effector protein AnkG (CBU0781) to understand how C. burnetii manipulates host cell viability. We demonstrate by RNA-immunoprecipitation that AnkG binds to the host cell 7SK snRNA, an important regulator of the positive tra...
ORGANISM(S): Homo sapiens 
2021-10-08 | GSE185428 | GEO
UnknownThe anti-apoptotic Coxiella burnetii effector protein AnkG is a strain specific virulence factor.
Not available
S-EPMC7506536 | biostudies-literature
UnknownThe Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription.
Not available
S-EPMC8824381 | biostudies-literature
TranscriptomicsAge-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG
The bipolar disorder (BD) risk gene ANK3 encodes the scaffolding protein AnkyrinG(AnkG). In neurons, AnkG regulates polarity and ion channel clustering at axon initial segments and nodes of Ranvier. Disruption of neuronal AnkG causes BD-like phenotypes in mice. During development, AnkG is also expre...
ORGANISM(S): Mus musculus 
2024-04-12 | GSE263546 | GEO
TranscriptomicsLoss of Neurofascin 186 and Ankyrin G in Purkinje Cells Causes Disruption of Axon Initial Segments, Neurodegeneration and Cerebellar Ataxia
The axon initial segment (AIS) is essential for initiating action potentials and maintaining neuronal polarity, yet the developmental roles of its core molecular components—Neurofascin 186 (NF186) and Ankyrin G (AnkG)—remain incompletely defined in cerebellar Purkinje cells. Here, we generated Purki...
ORGANISM(S): Mus musculus 
2026-03-27 | GSE322737 | GEO
UnknownAge-dependent regulation of axoglial interactions and behavior by oligodendrocyte AnkyrinG.
Not available
S-EPMC11686269 | biostudies-literature
UnknownStructural basis for the membrane association of ankyrinG via palmitoylation.
Not available
S-EPMC4820748 | biostudies-literature
UnknownEarly and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons.
Not available
S-EPMC5354314 | biostudies-literature
UnknownAnkyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
Not available
S-EPMC6570423 | biostudies-literature
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