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MetabolomicsOverexpression of Brassica napus COMT1 in Arabidopsis heightens UV-B-mediated resistance to Plutella xylostella herbivory

UV-B radiation regulates numerous morphogenic, biochemical and physiological responses in plants, and can stimulate some responses typically associated with other abiotic and biotic stimuli, including invertebrate herbivory. Removal of UV-B from the growing environment of various plant species ha...

2023-08-14 | MTBLS8236 | MetaboLights
TranscriptomicsTranscription profiling by array of Streptomyces coelicolor actinorhodin-producing wild type andrecombinant strains
Genome-wide expression analysis of 6 batch cultivations of actinorhodin-producing wild type and recombinant strain of Streptomyces coelicolor
ORGANISM(S): Streptomyces coelicolor A3(2) 
2010-05-25 | E-MTAB-306 | biostudies-arrayexpress
TranscriptomicsLenalidomide-mediated enhanced translation of C/EBP?-p30 protein upregulates expression of the anti-leukemic microRNA-181a in acute myeloid leukemia - microRNA Data
Recently, we showed that increased miR-181a expression was associated with improved outcomes in cytogenetically normal acute myeloid leukemia (CN-AML). Interestingly, miR-181a expression was increased in CN-AML patients harboring CEBPA mutations, which are usually biallelic and associate with better...
ORGANISM(S): Homo sapiens 
2012-10-04 | E-MTAB-1320 | biostudies-arrayexpress
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsTranscription profiling of non squamous cell lung cancer cell lines to investigate sensititivity to gefitinib and predict this in previously untested cell lines
Eleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression. Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity. A subset of the test set data was tested for gefitinib sensitivity, and...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-4342 | biostudies-arrayexpress
GenomicsPS
Psoriasis cases as part of WTCCC2 phase 2
EGAD00010000124 | EGA
GenomicsGenome wide association scan in psoriasis
To identify novel susceptibility loci for psoriasis, we undertook a genome-wide association scan of of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls.
EGAS00000000108 | EGA
TranscriptomicsBulk ATAC-seq experiments on human samples from normal gastric cardia, normal oesophageal submucosal glands and Barrett's oesophagus tissue
Profiling open chromatin in different tissue types around the gastro-oesophageal junction to allow for clustering of samples and investigation of transcription factor binding site motif enrichment.
ORGANISM(S): Homo sapiens 
2021-08-24 | E-MTAB-10044 | biostudies-arrayexpress
TranscriptomicsEffects of DHT on the ovary of fathead minnow
Fathead minnow ovary explants were incubated with DHT at 10^-6M for 6, 9, and 12 hours. Estrogen production was significantly increased in these ovaries at all three time points. control 6 hours (n=4), DHT 6 hours (n=5), control 9 hours (n=5), DHT 9 hours (n=5), control 12 hours (n=4), DHT 12 hours ...
ORGANISM(S): Pimephales promelas 
2012-07-30 | E-GEOD-38289 | biostudies-arrayexpress
TranscriptomicsThe ureic-based herbicide linuron and the model anti-androgen flutamide regulate common gene networks in the fathead minnow (Pimephales promelas) ovary
The herbicide linuron is an endocrine disruptor with a suspected anti-androgenic mode of action (MOA) but the complete MOA for LIN is not fully characterized. The objectives of this study were to better characterize the MOA of LIN in the fathead minnow (FHMs) ovary by comparing expression profiles ...
ORGANISM(S): Pimephales promelas 
2012-07-01 | E-GEOD-38287 | biostudies-arrayexpress
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