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MetabolomicsThe Role of Annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

Annexin A1 (AnxA1) is an anti-inflammatory protein present in different cells in biological systems, especially expressed in macrophages and neutrophils. Since neutrophils play an important role in infections and inflammatory processes and the AnxA1 and its relation in Candida spp. infections is ...

2021-12-03 | MTBLS2288 | MetaboLights
TranscriptomicsInvestigation of over-expressing Annexin receptor cell line with and without agonists
The therapeutic potential of pro-resolution factors in determining the outcome of inflammatory events has gained ground over the past decade. However, the attention has been focused on the non-genomic effects of these endogenous, anti-inflammatory substances. In this study, we have focused our atten...
ORGANISM(S): Homo sapiens 
2010-09-28 | E-GEOD-14807 | biostudies-arrayexpress
TranscriptomicsExpression signatures of human HeLa cells with RNAi targetting A1 hnRNP, FUS, H hnRNP and p68-DDX5
Transcription profiling of human HeLa cells (cervical cancer cell line) transfected with a plasmid expressing shRNAs cloned into the pSuper expression vector compared to emprty vector negative controls for transfection. Four different RNA interference treatments targetted: A1 hnRNP (HNRNPA1, Heterog...
ORGANISM(S): Homo sapiens 
2008-08-20 | E-GEOD-12058 | biostudies-arrayexpress
ProteomicsPathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury
Intestinal ischemia-reperfusion (IR) injury is initiated when natural IgM antibodies recognize neo-epitopes that are revealed on ischemic cells. The target molecules and mechanisms whereby these neo-epitopes become accessible to recognition are not well understood. Proposing that isolated intestinal...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14862 | biostudies-arrayexpress
GenomicsAnnexin A1 exerts renoprotective effects in experimental crescentic glomerulonephritis
Annexin A1 exerts renoprotective effects in experimental crescentic glomerulonephritis
PRJNA842654 | ENA
ProteomicsAnnexin A1 interacting proteins in chronic myeloid leukemia KCL22 cells
In the present study, we used a functional proteomic approach to identify Annexin A1 (Anxa1) interacting proteins in the Philadelphia-positive KCL22 cell line. We focused on Anxa1 because it is one of the major proteins upregulated in imatinib-sensitive KCL22S cells versus imatinib-resistant KCL22R....
ORGANISM(S): Homo sapiens (Human) 
2013-08-13 | PXD000030 | Pride
Annexin a1 Protein interaction Chronic myeloid leukemia 
ProteomicsAnnexin A1 is a polarity cue that directs planar mitotic spindle orientation during mammalian epithelial morphogenesis
Oriented cell divisions are critical for the formation and maintenance of structured epithelia. Proper mitotic spindle orientation relies on polarised anchoring of force generators to the cell cortex by the evolutionarily conserved Gαi-LGN-NuMA complex. However, the polarity cues that control cortic...
ORGANISM(S): Homo sapiens (Human) 
2022-12-02 | PXD027452 | Pride
Mammary Proteomics Annexin a1 
TranscriptomicsTranscription profiling of human peripheral blood monocytes treated with Annexin A1 Ac1-25 vs. unstimulated
We used microarrays to detail the global gene expression changes elicited by stimulation of human peripheral blood monocytes from buffy coats with 50µM Annexin A1 peptide Ac1-25 for 2h versus unstimulated control monocytes. Experiment Overall Design: three independent monocyte isolations each were ...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9080 | biostudies-arrayexpress
TranscriptomicsAnnexin A1 exerts renoprotective effects in experimental crescentic glomerulonephritis
The glucocorticoid-inducible protein annexin A1 has been shown to function as key-regulator of the resolution phase of inflammation but its role in immune-mediated crescentic glomerulonephritis has not been studied so far. Acute crescentic glomerulonephritis was induced in annexin A1 deficient and w...
ORGANISM(S): Mus musculus 
2022-10-04 | GSE204873 | GEO
TranscriptomicsTranscription profiling by array of human breast cancer cell line BT-474 with annexin A1 over-expression or silenced with siRNA to demonstrate design of multi-condition experiments
Multiple-condition experiment was desinged to be any number of conditions in an experiment without replicate observations for microarray and used to identify genes differentially expressed between different pairs of conditions (treatments).
In this study we used breast cancer stable cell lines f...
ORGANISM(S): Homo sapiens 
2010-06-26 | E-MEXP-2775 | biostudies-arrayexpress
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