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TranscriptomicsLigand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
The discovery that enhancers are regulated transcription units, encoding eRNAs, has raised new questions about the mechanisms of their activation. Here, we report an unexpected molecular mechanism that underlies ligand-dependent enhancer activation, based on DNA nicking to relieve torsional stress f...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-63202 | biostudies-arrayexpress
UnknownNovel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity.
Not available
S-EPMC6409185 | biostudies-literature
UnknownThr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations.
Not available
S-EPMC2553568 | biostudies-literature
UnknownAssociation of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.
Not available
S-EPMC2895677 | biostudies-literature
UnknownMycoplasma fermentans inhibits the activity of cellular DNA topoisomerase I by activation of PARP1 and alters the efficacy of its anti-cancer inhibitor.
Not available
S-EPMC3754970 | biostudies-literature
GenomicsDNA Topoisomerase 1M-NM-1 Promotes RNA-directed DNA Methylation and Histone Lysine 9 Dimethylation at Transposable Elements in Arabidopsis [Bisulfite-Seq]
RNA-directed DNA methylation (RdDM) is a transcriptional silencing mechanism mediated by small and long noncoding RNAs produced by the plant-specific RNA polymerases Pol IV and Pol V, respectively. Through a chemical genetics screen with a luciferase-based DNA methylation reporter, LUCL, we found th...
ORGANISM(S): Arabidopsis thaliana 
2014-07-07 | E-GEOD-50691 | biostudies-arrayexpress
TranscriptomicsDNA Topoisomerase 1a Promotes RNA-directed DNA Methylation and Histone Lysine 9 Dimethylation at Transposable Elements in Arabidopsis [RNA-Seq]
RNA-directed DNA methylation (RdDM) is a transcriptional silencing mechanism mediated by small and long noncoding RNAs produced by the plant-specific RNA polymerases Pol IV and Pol V, respectively. Through a chemical genetics screen with a luciferase-based DNA methylation reporter, LUCL, we found th...
ORGANISM(S): Arabidopsis thaliana 
2014-07-08 | E-GEOD-50719 | biostudies-arrayexpress
GenomicsChemical profiling of the genome with anti-cancer drugs defines target specificities
Many anti-cancer drugs induce DNA breaks to eliminate tumor cells. The anthracycline topoisomerase II inhibitors can also evict histones. We performed a genome-wide high-resolution mapping of chemotherapeutic effects of various topoisomerase I and II inhibitors. We show that different drugs target d...
ORGANISM(S): Homo sapiens 
2015-05-10 | E-GEOD-60395 | biostudies-arrayexpress
UnknownAmsacrine Derivatives Selectively Inhibit Mycobacterial Topoisomerase I (TopA), Impair M. smegmatis Growth and Disturb Chromosome Replication.
Not available
S-EPMC6056748 | biostudies-literature
ProteomicsImmunoglobulins G from Systemic Sclerosis Patients Modify the Proteome of Endothelial Cells Depending on Antinuclear Antibodies Serotypes
Systemic sclerosis (SSc) is a heterogeneous connective tissue disease characterized by autoimmunity, vasculopathy and excessive fibrosis (1). Antinuclear antibodies (ANA) are strong diagnostic and prognosis biomarkers but their pathogenicity in fibrosis and vasculopathy remains unclear. Functional a...
ORGANISM(S): Homo sapiens (Human) 
2025-03-24 | PXD049364 | Pride
Systemic sclerosis Igg Endothelial cells Proteomics Antinuclear antibodies 
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