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TranscriptomicsThe roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus
We investigated the roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus (DENV). Double-deficient Irf-3-/-7-/- mice infected with the DENV2 strain S221 possessed 1,000-150,000 fold higher levels of viral RNA than wild-type and single-deficient mice 24 hours after infection; how...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-49871 | biostudies-arrayexpress
TranscriptomicsPeroxisomes are signaling patforms for antiviral innate immunity
Analysis of the transcriptional response of mouse embryonic fibroblasts to reovirus infection. The hypothesis tested was that both peroxisomal and mitochondrial MAVS is capable of inducing the expression of antiviral genes. mRNA isolated from MAVS-expressing cells after infection for various times ...
ORGANISM(S): Mus musculus 
2010-11-04 | E-GEOD-21215 | biostudies-arrayexpress
MetabolomicsSurvival of the littlest: Navigating sepsis diagnosis beyond inflammation in preterm neonates
Background Sepsis diagnosis in preterm neonates is challenging due to symptom overlap with non-infectious inflammatory conditions, and slow, unreliable diagnostic practices. This study aims to identify metabolic biomarkers to elucidate sepsis pathophysiology, and enable timely, accurate diagnosis, w...
2025-07-07 | MTBLS10665 | MetaboLights
TranscriptomicsIntragraft anti-viral-specific gene expression as a distinctive transcriptional signature for polyomavirus-associated nephropathy
Polyoma virus nephropathy (PVAN) is a common cause of kidney allograft dysfunction and loss. Microscopic descriptions of PVAN are very similar to T-cell mediated rejection (TCMR) and have unclear underlying molecular mechanisms. To identify PVAN-specific gene expression, we analyzed 162 kidney biops...
ORGANISM(S): Homo sapiens 
2016-09-30 | E-GEOD-72925 | biostudies-arrayexpress
ProteomicsComprehensive proteomics identification of IFN-λ3-regulated anti-viral proteins in HBV-transfected cells
Hepatitis B virus (HBV) causes both acute and chronic liver inflammation. Approximately 600,000 CHB patients each year die of HBV-related diseases such as cirrhosis and liver cancer. Therefore, CHB remains a global health concern. Although there have been anti-HBV agents for treating CHB, they have ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-17 | PXD007896 | Pride
Hepatitis b virus Ifn-λ3 Dimethyl labeling Lc-ms/ms 
GenomicsA UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection
A UL26-PIAS1 complex antagonizes anti-viral gene expression during Human Cytomegalovirus infection
PRJNA1103198 | ENA
TranscriptomicsModeling regulatory relationships in Arabidopsis immune signaling network.
Expression profiles of 22 reference Arabidopsis immunity mutants were collected using the Arabidopsis Pathoarray 464_001 (GPL3638) in order to build a network model predicting the Arabidopsis immune signaling network. Biological signaling processes may be mediated by complex networks in which netwo...
ORGANISM(S): Arabidopsis thaliana 
2010-07-22 | E-GEOD-19663 | biostudies-arrayexpress
GenomicsThe roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity [ChIP-seq]
The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity [ChIP-seq]
PRJNA1050147 | ENA
GenomicsThe roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity [RNA-seq]
The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity [RNA-seq]
PRJNA1050148 | ENA
UnknownManipulating TLR Signaling Increases the Anti-tumor T Cell Response Induced by Viral Cancer Therapies.
Not available
S-EPMC4830920 | biostudies-literature
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