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MetabolomicsMetabolomics analysis of antibacterial mechanism
Metabolomics, as a high-throughput analytical technique, enables comprehensive analysis of the metabolic changes in microorganisms under different environmental conditions, revealing the molecular basis of their antibacterial mechanisms. This study employs metabolomics analysis to investigate the an...
2025-04-25 | MTBLS11717 | MetaboLights
MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
TranscriptomicsAn essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity.
Type I interferons were discovered as the primary antiviral cytokines and are now known to serve critical functions in host defense against bacterial pathogens. Accordingly, established mediators of interferon antiviral activity may mediate previously unrecognized antibacterial functions. RNase-L is...
ORGANISM(S): Mus musculus 
2008-12-19 | E-GEOD-13530 | biostudies-arrayexpress
MetabolomicsPomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs
Plant extracts are rich in bioactive compounds, such as polyphenols, sesquiterpenes, and triterpenes, which potentially have antiviral activities. As a consequence of the coronavirus disease 2019 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus, thousands of...
2021-10-06 | MTBLS2309 | MetaboLights
ProteomicsAntibacterial properties and mechanism of action for serum obtained from the Chinese alligator (Alligator sinensis)
Chinese alligator (Alligator sinensis) is one of the rarest endangered reptiles found in China and possesses strong immune potential. This study tested the antibacterial ability of Chinese alligator serum (CAS) against Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, and Pseudomonas a...
ORGANISM(S): Alligator sinensis 
2023-03-10 | PXD017090 | Pride
Protein Antibacterial Alligator sinensis Complement system Serum 
ProteomicsIdentification of proteolytic fragments of human hemoglobin
The uploaded data is related to the identification of the antibacterial/antiviral human peptide HBB 12-147 in hemoglobin digestion with Napsin-A
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-12-15 | MSV000086600 | MassIVE
GenomicsMetal drugs as antibacterial agents
The antibacterial activity of novel 1,10-phenanthroline complexes of Cu(II), Mn(II) and Ag(I) against multidrug-resistant clinical isolates derived from Irish patients
PRJEB53038 | ENA
TranscriptomicsMycobacterium tuberculosis H37Rv transcriptional response to antibacterial agents
Bacteria commonly adapt to stresses by altering gene expression. To understand the response of M. tuberculosis (MTB) to various antibacterial agents, we performed transcriptomics on MTB bacilli exposed to several test compounds as well as known drugs (capreomycin, cycloserine, ethionamide, isoniazi...
ORGANISM(S): Mycobacterium tuberculosis 
2015-11-11 | E-GEOD-71200 | biostudies-arrayexpress
UnknownBrief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity.
Not available
S-EPMC8341851 | biostudies-literature
MetabolomicsSmall Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies
The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integr...
2021-11-04 | MTBLS788 | MetaboLights
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