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MetabolomicsMetabolomic-based investigation on the effects of antifungal agents in Candida albicans
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ORGANISM(S): Candida albicans 
ST000243 | MetabolomicsWorkbench
MetabolomicsBioinspired Rhamnolipid Protects Wheat Against Zymoseptoria tritici Through Mainly Direct Antifungal Activity and Without Major Impact on Leaf Physiology

Rhamnolipids (RLs), glycolipids biosynthesized by the Pseudomonas and Burkholderia genera, are known to display various activities against a wide range of pathogens. Most previous studies on RLs focused on their direct antimicrobial activity, while only a few reports described t...

2022-06-21 | MTBLS4542 | MetaboLights
TranscriptomicsGene expression response to the antifungal compound sampangine
Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analy...
ORGANISM(S): Candida albicans 
2010-05-26 | E-GEOD-10104 | biostudies-arrayexpress
TranscriptomicsAspergillus fumigatus Af293 response to lactic acid bacteria antifungal activity
The effect of cell free supernatant from the antifungal strain Lactobacillus plantarum 16 on the growth of Aspergillus fumigatus Af293 was assessed. Transcriptome analysis of the genome was performed after ten minutes exposure to antifungal supernatant in order to determine the molecular targets inv...
ORGANISM(S): Aspergillus fumigatus 
2013-08-09 | E-MTAB-1701 | biostudies-arrayexpress
no omics definedTranscription profiling of Candida albicans biofilm exposed to amphotericin B, fluconazole or two concentrations of caspofungin
30h of growth biofilms in microfermentors were exposed to caspofungin 0.5 µg/ml, caspofungin 5 µg/ml, fluconazole 80 µg/ml or amphotericin B 8 µg/ml. Control and antifungal-exposed biofilms were recovered at t= 0, 30, 60 and 120 min post exposure to antifungal.
ORGANISM(S): Candida albicans 
2010-03-02 | E-MEXP-2436 | biostudies-arrayexpress
TranscriptomicsGene expression response to the antifungal compound sampangine in C. albicans
Sampangine, a plant-derived alkaloid found in the Annonaceae family, exhibits strong inhibitory activity against the opportunistic fungal pathogens Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. In the present study, transcriptional profiling experiments coupled with the analy...
ORGANISM(S): Candida albicans 
2010-05-26 | E-GEOD-10075 | biostudies-arrayexpress
TranscriptomicsResponse of Candida albicans towards a novel antifungal benzimidazole derivative
Fungal infections are a serious health problem in the clinic especially in the immunocompromised patient. Disease ranges from widespread superficial vulvovaginal infections to life-threatening systemic candidiasis. Especially for systemic mycoses only a limited arsenal of antimycotica are available,...
ORGANISM(S): Candida albicans 
2011-07-14 | E-GEOD-21622 | biostudies-arrayexpress
TranscriptomicsApoEdpL-W treatment
We performed a gene expression analysis of C. albicans SC5314 planktonic cells exposed to the antifungal peptide ApoEdpL-W. Exponentially-growing C. albicans SC5314 cells in SD at 30°C medium were exposed to 2.5 µM ApoEdpL-W and samples were collected after 10 and 30 min. for transcript profiling
ORGANISM(S): Candida albicans 
2011-04-01 | E-MEXP-3084 | biostudies-arrayexpress
TranscriptomicsIndolic metabolites are required for antifungal defense of the Arabidopsis mlo2 mutant
Arabidopsis thaliana genes MLO2 (Mildew resistance locus-O 2), MLO6 and MLO12 exhibit unequal genetic redundancy with respect to the modulation of defense responses against powdery mildew fungi and the control of developmental phenotypes such as premature leaf decay. We show that early chlorosis and...
ORGANISM(S): Arabidopsis thaliana 
2010-01-03 | E-GEOD-17875 | biostudies-arrayexpress
TranscriptomicsMicroarray of Candida albicans treated with sublethal concentrations of the antifungal Jagaricin
Candida albicans were treated with a sublethal concentration of the antifungal Jagaricin for either a short time (30 min) or until an OD of 0.5 (indicating log growth) was reached. Controls were grown without any antifungal to determine cellular reactions to the compound.
ORGANISM(S): Candida albicans 
2019-06-14 | E-MTAB-7718 | biostudies-arrayexpress
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