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MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
TranscriptomicsIncreased antigen cross-presentation but impaired cross-priming after activation of PPARγ
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ is mediated by up-regulation of B7H1 Dendritic cells (DCs) are able to take up exogenous antigens and present antigen-derived peptides on MHC class I molecules, a process termed cross-presentation. The mannose...
ORGANISM(S): Mus musculus 
2010-05-08 | E-GEOD-15616 | biostudies-arrayexpress
ModelsSontag2017 - Dynamic model of immune responses to antigen presentation by tumor or pathogen
This model of the immune system response to antigen presentation is based on the publication: Eduardo D.Sontag (2017) 'A Dynamic Model of Immune Responses to Antigen Presentation Predicts Different Regions of Tumor or Pathogen Elimination', Cell Systems, 4(2) DOI: 10.1016/j.cels.2016.12.003 Comment...
2024-09-02 | BIOMD0000001030 | BioModels
ProteomicsTumor-derived CDC37 inhibits antigen cross-presentation in dendritic cells and impairs anti-tumor immunity in breast cancer
Tumor mutational burden (TMB), usually representing high immunogenicity, could not always predict treatment response of immune checkpoint blockade (ICB). Here, we showed that defective antigen cross-presentation in type 1 conventional dendritic cells (cDC1) was responsible for lacking tumor-specific...
ORGANISM(S): Homo Sapiens 
PXD069576 |
TranscriptomicsTranscription profiling of human CD4+ T cells induced by HIV-1 gp120/V3 loop peptides, time series
Comparative changes of gene expression in human primary CD4+ T cells induced by HIV-1 gp120/V3 loop synthetic peptides, during antigen presentation
ORGANISM(S): Homo sapiens 
2008-09-01 | E-MEXP-1586 | biostudies-arrayexpress
ProteomicsMass spectrometry of HLA-I peptidomes reveals strong effects of protein abundance and turnover on antigen presentation
HLA class I molecules reflect the health state of cells to cytotoxic T-cells by presenting a repertoire of endogenously derived peptides. However, the extent to which the proteome shapes the peptidome is still largely unknown. Here we present a high-throughput mass-spectrometry-based workflow that a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-29 | MSV000079539 | MassIVE
TranscriptomicsTranscription profiling of mouse dendritic subsets in vivo
Dendritic cells (DCs) process and present self and foreign antigens to induce tolerance or immunity. In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo. To examine antigen ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6259 | biostudies-arrayexpress
ProteomicsHLA-DM allotypes - Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4+ T cell activation
Major Histocompatibility Complex of Class II (MHCII) antigen presentation is a key event of adaptive immunity. HLA-DM favors the presentation of kinetically stable peptide-MHCII complexes but does not bind peptides itself and exhibits only a low degree of polymorphism. To date, no evidence for alter...
ORGANISM(S): Homo sapiens (Human) 
2018-10-31 | PXD009791 | Pride
Antigen presentation/ mhc class ii/ immunopeptidome/ peptide editing/ polymorphism 
ProteomicsCT26 Proteome and Immunopeptidome treated with Ionizing Radiation
This project explored the relationship between ionizing radiation and antigen presentation using both proteomic and immunopeptidomics methodologies. We investigated the radiation-specific changes which occur in the colorectal tumor cell proteome associated with changes in dose and time after irradia...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-04 | PXD032003 | Pride
Interferon signaling Ligandomics Mhc Ionizing radiation Immunopeptidomics 
ProteomicsA red blood cell-based antigen delivery system to facilitate T cell epitope presentation to induce peripheral tolerance to ADAMTS13 in immune-mediated TTP
Aims Leveraging the tolerogenic nature of their natural clearance pathway, we aim to exploit red blood cells (RBCs) as an antigen delivery system to achieve persistent exposure to ADAMTS13-derived peptides, promoting antigen-specific attenuation of autoreactive CD4+ T cells and induction of regulato...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD064980 | Pride
Adamts13 Ittp Immunopeptidomics Antigen presentation 
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