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TranscriptomicsTranscriptomic profiling of antigen-specific T cells at the single-cell level after clearance of hepatitis C virus
We used scRNA-seq data generated using Smart-seq2 to reconstruct the native TCR from Ag-specific T cells and then to link these with the gene expression profile of individual cells. antigen specific CD8 T cells were obtained from a subject who had previously cleared hepatitis C virus (HCV) infection...
ORGANISM(S): Homo sapiens 
2017-01-31 | E-MTAB-4850 | biostudies-arrayexpress
TranscriptomicsHomo sapiens PBMCs: pre-vaccination (stimulation vs. no stimulation with EV71 antigen) vs. post-vaccination (stimulation vs. no stimulation with EV71 antigen)
To characterize the primary and recall responses to EV71 vaccines, PBMC from 19 recipients before and after vaccination with EV71 vaccine are collected and their gene expression signatures after stimulation with EV71 antigen were compared. Four-condition experiment,pre-vaccination PBMCs (stimulation...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-72618 | biostudies-arrayexpress
TranscriptomicsModulation of brain dead induced inflammation by vagus nerve stimulation
Because the vagus nerve is implicated in control of inflammation, we investigated if brain death causes impairment of the parasympathetic nervous system, hence contributing to inflammation. Brain death (BD) was induced in rats. Anaesthetised ventilated rats (NBD) served as control. Heart rate varia...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-16483 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T cells to determine the strength of T cell stimulation
The strength of T cell stimulation determines IL-7 responsiveness, recall potential and lineage commitment of primed human CD4+IL-7Rhi T cells; We analyzed how the strength of antigenic stimulation - as determined by dendritic cell (DC) number, DC maturation state and antigen concentration - control...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6566 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of BDC2.5 CD4T cells isolated from NOD mice after in vivo antigen stimulation with either DEC205+ or DCIR2+ DCs.
We identified DCIR2+DCs but not DEC205+DCs as able to induce peripheral T cell tolerance in pre-diabetic autoimmune NOD mice. To determine what distinct genetic programs are elicited in the auto-reactive CD4 T cells early after stimulation by these two DC subsets, we utilized adoptive transfer of BD...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-69554 | biostudies-arrayexpress
TranscriptomicsGeneration and purification of Th1 and Th2 effector and memory CD4+ T cells
Naïve CD4+ T cells were isolated from spleen of AND TcR transgenic/green fluorescence protein (GFP) transgenic mice (Kaye et al., Nature 1989;341:746, Wright et al, Blood 2001;97:2278) that recognize a peptide of pigeon cytochrome C in the context of I-Ek and express CD44lo, CD62Lhi, CD45RBhi, and ...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-8352 | biostudies-arrayexpress
TranscriptomicsMouse Soleus Muscle Chronic Electrical Stimulation Study
Stimulation of the mouse hindlimb via the sciatic nerve was used to induce contractions for 4 hours to investigate acute muscle gene activation in a model of muscle phenotype conversion. Initial force production (1.6 + 0.1 g/g body weight) declined 45% within 10 min and was maintained for the remain...
ORGANISM(S): Mus musculus 
2010-06-01 | E-GEOD-14391 | biostudies-arrayexpress
TranscriptomicsExpression data from antigen-specific CD4+T cells from peripheral blood of patietns with CD and healthy controls.
Crohn's Disease (CD) is a chronic inflammatory disease of the intestinal tract. We performed a whole-genome transcriptional analysis using sorted commensal antigen-specific CD4+T cells from peripheral blood of CD patients and from healthy controls. Peripheral blood sorted FlaX, Fla2 and YidX-specifi...
ORGANISM(S): Homo sapiens 
2016-07-27 | E-GEOD-70469 | biostudies-arrayexpress
GenomicsAntigen-independent stimulation of effector CD4+ T cells protects from fibrotic remodelling in myocarditis
Antigen-independent stimulation of effector CD4+ T cells protects from fibrotic remodelling in myocarditis
PRJEB28775 | ENA
ProteomicsExtracellular Domains of CAR Reprogram T Cell Metabolism Without Antigen Stimulation
Phosphopeptides of CARs in 14g2a-based anti-GD2, Leu16 anti-CD20, rituximab anti-CD20, and RFR-LCDR anti-CD20 CAR-T cells without antigen stimulation
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-11 | MSV000093637 | MassIVE
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