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TranscriptomicsExpression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection
CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transf...
ORGANISM(S): Mus musculus 
2013-04-22 | E-GEOD-43863 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of presenilin deficient DP thymocytes
Notch1 signaling is an important regulator of cell fate in early stages of T cell development. Because Notch receptors can function redundantly, we sought an approach for inhibiting all endogenous Notch signaling in thymocytes. Upon ligand engagement, Notch receptors undergo two successive proteo...
ORGANISM(S): Mus musculus 
2007-09-14 | E-GEOD-6590 | biostudies-arrayexpress
ProteomicsA metabolism-epigenome axis controls early events in CD4+ T cell activation
Upon antigen-specific T Cell Receptor (TCR) engagement, human CD4+ T cells proliferate and differentiate, a process associated with rapid transcriptional changes and metabolic reprogramming utilizing aerobic glycolysis together with maintenance of oxidative phosphorylation1,2. However, the role of g...
ORGANISM(S): Homo sapiens (Human) 
2023-10-27 | PXD018132 | Pride
Human cd4+ t cells Antigen-specific t cell receptor (tcr) engagement 
TranscriptomicsAffinity and Dose of TCR Engagement Yield Proportional Enhancer and Gene Activity in CD4+ T Cells
Affinity and dose of T cell receptor (TCR) interaction with antigens govern the magnitude of CD4+ T cell responses, but questions remain regarding the quantitative translation of TCR engagement into downstream signals. We find that while the response of CD4+ T cells to antigenic stimulation is bimod...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-69545 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human NKp80+ and NKp80- CD8+ CCR7- TCR alpha beta + T cells
We have performed whole genome expression arrays covering over 47000 transcripts comparing the transcriptional profile of NKp80+ to NKp80- CD8+ CCR7- alpha beta T cells. A highly similar global gene expression profile was observed between both memory phenotype T cell subsets. Interestingly, the majo...
ORGANISM(S): Homo sapiens 
2008-11-15 | E-GEOD-10178 | biostudies-arrayexpress
TranscriptomicsCheckpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor infiltrating CD8+ T cells
Coinhibitory receptor blockade is a promising strategy to boost immunity against a variety of human cancers. However, many patients still do not benefit from this treatment, and responders often experience immune-related toxicities. These issues highlight the need for improved understanding of check...
ORGANISM(S): Mus musculus 
2014-12-18 | E-GEOD-58722 | biostudies-arrayexpress
GenomicsT cell receptor-triggered nuclear actin network formation drives CD4 T cell effector functions
T cell receptor-triggered nuclear actin network formation drives CD4 T cell effector functions
PRJNA505494 | ENA
TranscriptomicsGene expression in dendritic cells stimulated with LPS in conditions allowing or inhibiting NFAT activation
Interleukin-2 (IL-2) is one of the molecules produced by mouse dendritic cells (DCs) after stimulation by Toll like receptor (TLR) agonists. By analogy with the events following T-cell receptor (TCR) engagement leading to IL-2 production we have observed that DC stimulation with lipopolysaccharide (...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-15718 | biostudies-arrayexpress
GenomicsTargeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy [TCR-seq]
Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy [TCR-seq]
PRJNA951781 | ENA
TranscriptomicsT cell receptor-triggered nuclear actin network formation drives CD4 T cell effector functions
T cell antigen receptor (TCR) signaling triggers selective cytokine expression to drive T cell proliferation and differentiation required for immune defense and surveillance. The nuclear signaling events responsible for specificity in cytokine gene expression upon T cell activation are largely unkno...
ORGANISM(S): Homo sapiens 
2018-11-15 | GSE122531 | GEO
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