Sort   by:  
 Page size 
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
MetabolomicsMechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum

The emergence of multi-drug resistant Plasmodium falciparum underscores the urgent need for new antimalarial therapies. SC83288, a novel chemical entity, is highly effective against P. falciparum both in vivo and in vitro, including strains resistant to artemisinin and partner drugs. Here, we sho...

2026-02-16 | MTBLS13911 | MetaboLights
TranscriptomicsEpigenetic marks reduce erythrocyte uptake of antimalarials
Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In P. falciparum, resistance is known to arise through genome-level changes such as mutations and gene duplications. We now report an epigenetic resistance mechanism involving genes...
ORGANISM(S): Plasmodium falciparum 
2013-06-03 | E-GEOD-47579 | biostudies-arrayexpress
MetabolomicsTargeting host glycolysis as a strategy for antimalarial development
Not available
ORGANISM(S): Homo sapiens 
ST001864 | MetabolomicsWorkbench
MetabolomicsPeroxide antimalarial treatment timecourse on ring-stage P. falciparum parasites
Not available
ORGANISM(S): Plasmodium falciparum;Homo sapiens 
ST001202 | MetabolomicsWorkbench
MetabolomicsPeroxide antimalarial treatment timecourse on trophozoite-stage P. falciparum parasites
Not available
ORGANISM(S): Plasmodium falciparum;Homo sapiens 
ST001201 | MetabolomicsWorkbench
MetabolomicsMetabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
Not available
ORGANISM(S): Plasmodium falciparum 
ST000441 | MetabolomicsWorkbench
MetabolomicsPeroxide antimalarial extended treatment timecourse on trophozoite-stage P. falciparum parasites
Not available
ORGANISM(S): Plasmodium falciparum;Homo sapiens 
ST001204 | MetabolomicsWorkbench
MetabolomicsPeroxide antimalarial treatment of K13-mutant and -wildtype P. falciparum parasites
Not available
ORGANISM(S): Plasmodium falciparum;Homo sapiens 
ST001205 | MetabolomicsWorkbench
MetabolomicsOpen source discovery of starting points for next generation chemoprotective antimalarial drugs (Biofocus 1)
Not available
ORGANISM(S): Homo sapiens 
ST001074 | MetabolomicsWorkbench
Sort   by:  
 Page size