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MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
MetabolomicsThe Role of Obesity and Adipocytes in Immune Activation on Antiretroviral Therapy
Not available
ORGANISM(S): Homo sapiens 
ST000250 | MetabolomicsWorkbench
TranscriptomicsTranscriptome analysis of primary monocytes from HIV+ patients with differential responses to therapy
This study aimed at investigating the monocytic transcriptome distinction between patients with sustained virus suppression (BDL) and patients with virological failure during highly active antiretroviral therapy (HAART). This study provides the first transcriptomic distinctions in monocytes between ...
ORGANISM(S): Homo sapiens 
2013-12-30 | E-GEOD-52900 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of peripheral blood mononuclear cells from HIV and HCV coinfected patients before and after 24 weeks of combined antiretroviral therapy.
We aim to characterize HIV and HCV coinfected patient response to combined antiretroviral therapy through genome-wide expression profiling of patients' periperhal blood mononuclear cells before and after treatment initiation (baseline and 24 weeks). Individuals with frank cirrhosis were excluded fr...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-56619 | biostudies-arrayexpress
ProteomicsProfiling of proteome changes in plasma of HIV-infected patients receiving antiretroviral therapy
Antiretroviral therapy (ART) prevents HIV-1 onward transmission and disease progression, leading to excellent prognosis people living with HIV-1 (PWH). However, significant side effects, complications and impaired immune reconstitution still persist along with ART. We aimed to profile proteome chang...
ORGANISM(S): Homo Sapiens 
2022-03-08 | PXD045070 |
TranscriptomicsMonocyte involvement in HIV-Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome at initiation of antiretroviral therapy
Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) is a common complication in HIV-TB co-infected patients receiving combined antiretroviral therapy (cART). While monocytes/macrophages play major roles in both HIV- and TB-infection individually, a putative contribution of ...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-MEXP-3618 | biostudies-arrayexpress
TranscriptomicsExpression data from rhesus macaque colon, jejunum, and lung
The mucosa that lines the respiratory and gastrointestinal (GI) tracts is an important portal of entry for pathogens and provides the frontline of immune defense against HIV infection. Using the simian immunodeficiency virus (SIV) rhesus macaque model, we have performed a comparative analysis of hos...
ORGANISM(S): Macaca mulatta 
2013-11-01 | E-GEOD-51615 | biostudies-arrayexpress
TranscriptomicsHIV Infection and Antiretroviral Therapy Have Divergent Effects on Mitochondria in Adipose Tissue
Exploratory microarray analysis identified significant changes in gene expression in adipose tissue. These included changes in genes regulating lipid and steroid metabolic processes and electron carrier activity in HIV-infected patients receiving antiretroviral therapy (ART). Additional genes invo...
ORGANISM(S): Homo sapiens 
2011-07-07 | E-GEOD-30310 | biostudies-arrayexpress
GenomicsAntiretroviral therapy during development impairs cardiac reverse remodeling in a rodent model
Antiretroviral therapy during development impairs cardiac reverse remodeling in a rodent model
PRJNA1441392 | ENA
GenomicsAnalysis of transcription in peripheral blood mononuclear cells from HIV-infected patients receiving antiretroviral therapy
Analysis of transcription in peripheral blood mononuclear cells from HIV-infected patients receiving antiretroviral therapy
PRJNA1262980 | ENA
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