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MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
TranscriptomicsRole for ISGF3II in the Antiviral Activity of IFN-gamma
Type-I (e.g. IFN-alpha, IFN-beta) and type-II IFNs (IFN-gamma) have antiviral, antiproliferative, and immunomodulatory properties. Both types of IFN signal through the Jak/STAT pathway to elicit antiviral activity, yet IFN-gamma is thought to do so only through STAT1 homodimers while type-I IFNs act...
ORGANISM(S): Homo sapiens 
2011-01-19 | E-GEOD-25113 | biostudies-arrayexpress
TranscriptomicsAn essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity.
Type I interferons were discovered as the primary antiviral cytokines and are now known to serve critical functions in host defense against bacterial pathogens. Accordingly, established mediators of interferon antiviral activity may mediate previously unrecognized antibacterial functions. RNase-L is...
ORGANISM(S): Mus musculus 
2008-12-19 | E-GEOD-13530 | biostudies-arrayexpress
ProteomicsEvidence for an RNAi-independent role of DICER-LIKE2 in conferring growth inhibition and basal antiviral resistance
Higher plants encode four or five DICER-LIKE (DCL) enzymes responsible for the production of small non-coding RNAs which function in RNA interference (RNAi). Different RNAi pathways in plants effect transposon silencing, antiviral defense and endogenous gene regulation. DCL2 acts genetically redunda...
ORGANISM(S): Arabidopsis Thaliana 
PXD046163 | panorama
GenomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses
This SuperSeries is composed of the following subset Series: GSE36241: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (ChIP-Seq) GSE37051: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression) Ref...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-37052 | biostudies-arrayexpress
TranscriptomicsIdentification of Alpha Interferon-Induced Genes Associated with Antiviral Activity in Daudi Cells and Characterization of IFIT3 as a Novel Antiviral Gene
A novel assay was developed for Daudi cells in which the antiviral (AV) and antiproliferative (AP) activities of interferon (IFN) can be measured simultaneously. Using this novel assay, conditions allowing IFN AV protection but no growth inhibition were identified and selected. Daudi cells were trea...
ORGANISM(S): Homo sapiens 
2011-10-11 | E-GEOD-32517 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of dendritic cells infected with Newcastle Disease Virus reveals that antiviral response is dictated by a choreographed cascade of transcription factors
The dendritic cell (DC) is a master regulator of immune responses. Pathogenic viruses subvert normal immune function in DCs through the expression of immune antagonists. Understanding how these antagonists interact with the host immune system requires knowledge of the underlying genetic regulatory n...
ORGANISM(S): Homo sapiens 
2010-03-08 | E-GEOD-18791 | biostudies-arrayexpress
TranscriptomicsCre-ERT mediated antiviral induction
In this work, we aimed at studying the impact of microRNAs on antiviral responses, using inducible deletion of one or two copies of Dicer1 (in Dicer-floxed x EsrCRE+ MEFs). Unexpectedly, we discovered that Cre-ERT activation by hydroxytamoxifen (OHT) alone, independent of Dicer1 dele...
ORGANISM(S): Mus musculus 
2016-05-18 | E-GEOD-72024 | biostudies-arrayexpress
TranscriptomicsIdentification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression)
We have used an unbiased systems approach to predict that a member of the forkhead family of transcription factors, FOXO3, is a negative regulator of a subset of antiviral genes. This prediction was validated using macrophages isolated from Foxo3-null mice. We detected significantly increased transc...
ORGANISM(S): Mus musculus 
2012-09-19 | E-GEOD-37051 | biostudies-arrayexpress
TranscriptomicsThe roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus
We investigated the roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus (DENV). Double-deficient Irf-3-/-7-/- mice infected with the DENV2 strain S221 possessed 1,000-150,000 fold higher levels of viral RNA than wild-type and single-deficient mice 24 hours after infection; how...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-49871 | biostudies-arrayexpress
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