Antiviral immunity

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Instrument Platform

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Publication Date

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UNIPROT ID/AC

P42225 (2)

CHEBI ID

CHEBI:49402 (2)
CHEBI:16269 (2)
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CHEBI:64575 (2)
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CHEBI:26271 (2)
CHEBI:18186 (2)
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CHEBI:16857 (2)
CHEBI:16737 (2)
CHEBI:27897 (2)
CHEBI:17596 (2)
CHEBI:17368 (2)
CHEBI:20067 (2)

Metabolite Name

Tiglylglycine (2)
Ketoleucine (2)
12-HETE (2)
Indoxyl sulfate (2)
3-Indolepropionic acid (2)
Taurine (2)
N-[2-Chloro-5-(Trifluoromethyl)Phenyl]-2-(4-Nitrophenyl)Acetamide (1)
(S)-Menthone 8-Thioacetate (1)
Tyr-Thr-Tyr (1)
Cyanidin 3-(6''-Acetyl-Galactoside) (1)
Pro-Val-His (1)
Peperomin B (1)
(3R,5S)-1-Pyrroline-3-Hydroxy-5-Carboxylic Acid (1)
Lacto-N-Triaose (1)
4-Hydroxyestrone-2-S-Glutathione (1)
Met-Asn-Ile (1)
(4-Hydroxy-3-Methoxyphenyl)Ethanol (1)
4-(4-Chlorophenyl)-N-(2-Pyridinylmethyl)Cyclohexanecarboxamide (1)
(S)-2-Amino-5-((4-Nitrophenyl)Amino)-5-Oxopentanoic Acid (1)
1-Arachidonoyl-2-Hydroxy-Sn-Glycero-3-Phosphate (1)
Phe-Glu-Ile (1)
Haloperidol Decanoate (1)
Tamoxifen-Ol (1)
Pisumic Acid (1)
1A,11B-Dihydro-4,9-Dimethylbenz[A]Anthra[3,4-B]Oxirene (1)
Phe-Leu-Ile (1)
Ganoderic Acid Mb (1)
Laurycolactone B (1)
Reduced Haloperidol (1)
Sl(13:2_O/16:2_O) (1)

First Public Date

2026 (130)
2025 (106)
2024 (89)
2023 (74)
2022 (52)
2021 (43)
2014 (38)
2020 (31)
2019 (29)
2017 (25)
2015 (15)
2018 (12)
2016 (11)
2013 (8)

Modelling Approach

Ordinary differential equation model (3)

Lab affiliation

Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK (5)
Technical University of Munich, School of Medicine, Institute of Virology, 81675 Munich, Germany (3)
Cambridge Institute for Medical Research, University of Cambridge (2)
Harald zur Hausen Institute of Virology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. (2)
State Key Laboratory of Oncology in South China (2)
University of Oxford University of Dundee (2)
1 Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada 2 Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada (1)
1- Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK, Canada (1)
Antiviral Immunomics, Bioengineering, Technical University of Denmark, Denmark (1)
Associate Professor of Medicine: Rheumatology Chair, Gene Therapy and Vaccines Graduate Program Director, RVCL Research Center University of Pennsylvania Perelman School of Medicine (1)
Biogen Inc., 225 Binney St, Cambridge, MA 02142, USA; Laboratory of Inflammation Research, School of Life Science, Handong Global University, 558 Handong-ro, Buk-gu, Pohang, Gyeongbuk 37554, Republic of Korea (1)
CEITEC, Masaryk University Molecular medicine, RNA and immunity, CEITEC, Masaryk University (1)
Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK (1)
Center Biomol. Struct. & Organization Head, Immunity and Immune Evasion Lab Bachelor of Health and Biomedical Sciences Honours (BH058) Program Manager School of Health and Biomedical Sciences | RMIT University PO Box 71 | Bundoora 3083 | Australia (1)
Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research and Department of Molecular and Translational Sciences, Monash University, Clayton, Victoria, Australia. (1)
Centre for Proteome Research, Dept. Biochemistry & Systems Biology, University of Liverpool, Liverpool, UK (1)
Centre for Virues Research, University of Glasgow (1)
China Pharmaceutical University (1)
Dana-Farber Cancer Institute, Harvard Medical School, Howard Hughes Medical Institute (1)
Department of Biochemistry Stanford Cancer Institute Stanford University Stanford, CA 94305, USA (1)
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver BC, Canada (1)
Department of Biomedical Sciences Rue du Bugnon 7 1005 Lausanne Switzerland (1)
Department of Immunology, Interfaculty Institute for Cell Biology, Eberhard Karls University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany (1)
Department of Microbiology and Cell Biology, Montana State Univeristy (1)
Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, 3000, Victoria, Australia. (1)
Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, Victoria 3000, Australia (1)
Department of Molecular Biology and Genetics, Aarhus University (1)
Department of Molecular Biology, Cristea Lab, Princeton University, Princeton, NJ, US (1)
Department of Molecular Biology, Princeton University (1)
Department of Pediatrics Medizinische Fakultät Carl Gustav Carus Technische Universität Dresden 01307 Dresden, Germany (1)

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Submitter Keywords

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Classification

bacteria (18)
viruses (9)

Modification

Not available (1)

Study type

Transcription profiling by array (115)
RNA-seq of coding RNA (25)
RNA-seq of non coding RNA (13)
RNA-seq of coding RNA from single cells (6)
ChIP-seq (4)
Transcription profiling by RT-PCR (3)
Other (3)
Animal - Two-color microarray (2)
Unknown experiment type (1)
One-color microarray (1)
Animal - High-throughput sequencing (1)
ATAC-seq (1)
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Release Date

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2016 (219)
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2014 (181)
2013 (135)
2012 (119)
2011 (89)
2026 (82)
2010 (70)
2009 (49)
2007 (35)
2008 (33)
2006 (19)
2005 (10)
2004 (6)
2003 (6)
2002 (3)
2001 (2)
2000 (1)

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Exercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights

Phosphoethanolamine Cytidylyltransferase 2 Integrates DAG Metabolism and TBK1 Activation to Regulate Antiviral Innate Immunity

Phosphatidylethanolamine (PE) biosynthesis is critical for membrane biology and cellular homeostasis. However, its specific role in antiviral innate immunity remains poorly understood. Here, we demonstrate that inhibition of phosphoethanolamine cytidylyltransferase 2 (PCYT2), a key enzyme in...

2026-05-07 | MTBLS14085 | MetaboLights

IFN-inducible phospholipid levels govern endosomal antiviral immunity

Not available

ORGANISM(S): Homo sapiens

ST002413 | MetabolomicsWorkbench

Viral-Induced Heme Accumulation Subverts TLR4bb-Mediated Antiviral Immunity by Triggering Gut Microbiota Dysbiosis, Metabolic Dysregulation, and Ferroptosis

This study identifies grass carp TLR4bb as a crucial hub coordinating antiviral immunity with heme metabolism, redox balance, and gut microbiota during GCRV-II infection. While TLR4bb recruits TIRAP/MyD88/TRIF to activate IFN signaling against the virus, its synergy with heme and viral sensing tr...

2026-01-23 | MTBLS13755 | MetaboLights

Nano-formulated bisphosphonate adjuvants simultaneously induce humoral and cellular immunity

Adjuvant is an important component of vaccines However, given the limitation of existing adjuvants in variety and mechanism, developing a unique and effective adjuvant is urgently needed for clinal applications. Recent studies have implicated that the mevalonate pathway plays an essential role in va...

2026-03-03 | MTBLS11696 | MetaboLights

Peroxisomes are signaling patforms for antiviral innate immunity

Analysis of the transcriptional response of mouse embryonic fibroblasts to reovirus infection. The hypothesis tested was that both peroxisomal and mitochondrial MAVS is capable of inducing the expression of antiviral genes. mRNA isolated from MAVS-expressing cells after infection for various times ...

ORGANISM(S): Mus musculus

2010-11-04 | E-GEOD-21215 | biostudies-arrayexpress

An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity.

Type I interferons were discovered as the primary antiviral cytokines and are now known to serve critical functions in host defense against bacterial pathogens. Accordingly, established mediators of interferon antiviral activity may mediate previously unrecognized antibacterial functions. RNase-L is...

ORGANISM(S): Mus musculus

2008-12-19 | E-GEOD-13530 | biostudies-arrayexpress

Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

Analysis of the transcriptional response of HEK293 or HEK293-STAT6 stable cell lines to poly(I:C) transfection. The hypothesis tested was that poly(I:C) transfection is capable of inducing the expression of STAT6-dependent antiviral genes. mRNA isolated from HEK293 or HEK293-STAT6 stable cell lines ...

ORGANISM(S): Homo sapiens

2011-11-21 | E-GEOD-26435 | biostudies-arrayexpress

Evidence for an RNAi-independent role of DICER-LIKE2 in conferring growth inhibition and basal antiviral resistance

Higher plants encode four or five DICER-LIKE (DCL) enzymes responsible for the production of small non-coding RNAs which function in RNA interference (RNAi). Different RNAi pathways in plants effect transposon silencing, antiviral defense and endogenous gene regulation. DCL2 acts genetically redunda...

ORGANISM(S): Arabidopsis Thaliana

PXD046163 | panorama

The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus

We investigated the roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus (DENV). Double-deficient Irf-3-/-7-/- mice infected with the DENV2 strain S221 possessed 1,000-150,000 fold higher levels of viral RNA than wild-type and single-deficient mice 24 hours after infection; how...

ORGANISM(S): Mus musculus

2013-08-15 | E-GEOD-49871 | biostudies-arrayexpress

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