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Differential Expression analysis in Drosophila pseudoobscura to identify cis-trans regulation
ORGANISM(S): Drosophila pseudoobscura 
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
To study the role of the protein YTHDF2 during female gametogenesis, its gene was conditionally deleted in oocytes. Total RNA samples from YTHDF2 deficient GV and MII oocytes (and control oocytes) were subjected to array profiling.
ORGANISM(S): Mus musculus 
Estrogen receptor (ER) expression and proliferative activity are established prognostic factors in breast cancer. In a search for additional prognostic motives we analyzed the gene expression patterns of 200 tumors of patients who were not treated by systemic therapy after surgery using a discovery ...
ORGANISM(S): Homo sapiens 
To study the impact of the proteins TUT4 and TUT7 on the transcriptome their genes were conditionally deleted in GV oocytes, MEFs, ECSs, liver and Bone marrow. Total RNA samples from the TUT4 and TUT7 deficient tissues/cells (together with their control tissues/cells) were subjected to array profili...
ORGANISM(S): Mus musculus 
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