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GenomicsChIPseq analyses in germinal center B cells
Germinal center B cells were isolated from human tonsil tissue and crosslinked. ChIP was performed on two distinct pools of germinal center cells, each obtained from 3-5 donors. The experiment includes two biological replicates (germinal center cell pools from different donors). ChIP was performed o...
ORGANISM(S): Homo sapiens 
2015-12-04 | E-GEOD-68349 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type or mir-155 deficient B cells after stimulation with LPS and IL4
Wild type or miR-155 deficient b cells from 5 individuals each were stimulated with LPS and IL4 for 24hs and profiled.
ORGANISM(S): Mus musculus 
2007-11-21 | E-MEXP-1325 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lymph node derived B cells from Traf2 and Traf3 B cell knockout mice and Baff tg mice
Tumor necrosis factor-associated factors 2 and 3 (TRAF2 and TRAF3) were shown to function in a co-operative and non-redundant manner to suppress nuclear factor-κB2 (NF-κB2) activation, gene expression and survival in mature B cells. In the absence of this suppressive activity, B cells developed in...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-10422 | biostudies-arrayexpress
TranscriptomicsSmall-RNA expression in normal and malignant mature B cells
Small-RNA profiles were generated for normal mature germinal center (GC) B cells and GC-derived lymphomas. Normal and tumor samples are derived from different donors.
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56354 | biostudies-arrayexpress
TranscriptomicsExpression profiles of murine FOXO1+/+ and FOXO1-null GC B cells
The pathways regulating the formation of the germinal center (GC) dark- (DZ) and light- (LZ) zones are unknown. We show that FOXO1 expression is restricted to the GC DZ and is required for DZ formation, since its absence in mice leads to the complete loss of DZ gene programs and the formation of LZ-...
ORGANISM(S): Mus musculus 
2015-12-04 | E-GEOD-69216 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of infection of EBV B cells with either p53 or wild type MVA at 3 time points
Effect of infection of EBV B cells with either p53 or wild-type MVA at 3 time points.
ORGANISM(S): Homo sapiens 
2004-05-05 | E-MEXP-69 | biostudies-arrayexpress
GenomicsIdentification of MLL2 regulated genes in germinal center B cells
Somatic mutations of the MLL2 methyltransferase gene represent a common genetic lesion in multiple cancer types. In diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL), these mutations are highly recurrent and occur early during tumorigenesis, suggesting a central role in transformati...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-67494 | biostudies-arrayexpress
UnknownAn Aurora B-RPA signaling axis secures chromosome segregation fidelity.
Not available
S-EPMC10212944 | biostudies-literature
TranscriptomicsmiR-28 expression in the Burkitt lymphoma cell line P3HR1
Burkitt lymphoma (BL) is a highly aggressive B cell non-Hodgkin lymphoma (B-NHL), which originates from germinal center (GC) B cells and harbors translocations deregulating the MYC oncogene. A comparative analysis of microRNAs (miRNAs) expressed in normal and malignant GC B cells identified miR-28 a...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56268 | biostudies-arrayexpress
TranscriptomicsA tRNA-derived microRNA modulates the DNA damage response and is downregulated in B cell lymphoma
Sequencing studies from several model systems have suggested that diverse and abundant small RNAs may derive from tRNA, but the function of these molecules remains undefined. Here we demonstrate that one such tRNA fragment, cloned from human B cells and designated CU1276, in fact possesses the func...
ORGANISM(S): Homo sapiens 
2012-12-19 | E-GEOD-42989 | biostudies-arrayexpress
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