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TranscriptomicsProfiling aorta from high fat diet (HFD)-fed ApoE KO and wild type C57BL6 mice
This program aimed to understand gene expression changes in aorta during atherosclerotic lesion progression with an objective to identify genes that may present new opportunities for drug intervention The HFD-fed ApoE KO mice aorta profiling data was analyzed by identifying genes that were up- and d...
ORGANISM(S): Mus musculus 
2013-03-22 | E-GEOD-31947 | biostudies-arrayexpress
ProteomicsProteomic analysis of apoE-KO mice liver exposed to inhaled silicon dioxide.
ApoE-KO mice were treated with silicon monoxide for 16 weeks. Protein abundance changes in relation to untreated control were measured in liver samples fractionated to cytosol and mitochondria by SWATH-MS.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD028547 | Pride
Swath Apoe-ko mice Liver Silicon dioxide 
ProteomicsProteomic analysis of liver cytosol and mitochondria of apoE-KO mice treated with TUG-891.
ApoE-KO mice were treated with FFAR4 agonist TUG-891 for 16 weeks. Protein abundance changes in relation to untreated control were measured in liver samples fractionated to cytosol and mitochondria by SWATH-MS.
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD028535 | Pride
Tug-891 Swath Apoe-ko mice Liver 
TranscriptomicsGene expression in aortic roots of Apoe KO mice with Nod1 stimulation
To explore the mechanisms underlying progression of atherosclerosis provoked by Nod1 ligand stimulation, we performed microarray gene expression profiling of aortic roots of 6- and 9-week-old Apoe KO mice with or without oral FK565 administration. A gene ontology analysis of the genes up-regulated i...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-48947 | biostudies-arrayexpress
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
GenomicsTranscriptional profiles of tumor-draining lymph node resident CD11c+ cells in wildtype versus APOE-KO mice
Transcriptional profiles of tumor-draining lymph node resident CD11c+ cells in wildtype versus APOE-KO mice
PRJNA1050216 | ENA
UnknownEzetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice.
Not available
S-EPMC3786446 | biostudies-literature
TranscriptomicsAortic macrophages and endothelial cells of apoE KO mice aortas after plaque regression induced apoE adenoviral transfer
Aortic macrophages and endothelial cells of apoE KO mice were sorted and analyzed by microarray 2 weeks after regression was induced by adenoviral transfer of apoE. Aortic macrophages (CD45+ F4/80+ CD11b+) and endothelial cells (CD45- CD31+) were sorted from apoE KO mice and the RNA extracted and hy...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-42691 | biostudies-arrayexpress
TranscriptomicsEffect of dietary cholesterol on gene expression in the liver of apoE-KO mice
Apolipoprotein E-knock out (apoE-KO) mouse is known as a model animal for atherosclerosis accompanied by spontaneous hypercholesterolemia. When apoE-KO mice were fed a chow supplemented with 1.25% cholesterol (high-Chol diet), cholesterol and bile acids were highly increased in the liver within a we...
ORGANISM(S): Mus musculus 
2011-08-07 | E-GEOD-27457 | biostudies-arrayexpress
TranscriptomicsExpression data from the hearts of a mouse model of spontaneous myocardial infarction
Mice with homozygous null mutations in the HDL receptor (SR-BI) and apoE genes (SR-BI KO/apoE double KO (dKO) mice) spontaneously develop occlusive, atherosclerotic coronary artery disease (CAD) and die prematurely (50% mortality at 42 days of age) on standard chow diet feeding. Microarray analysis ...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-49937 | biostudies-arrayexpress
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