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MetabolomicsSingle-cell time-resolved multi-omics reveal apoptotic and ferroptotic heterogeneity during foam cell formation

Macrophage-derived foam cell plays a pivotal role in the plaque formation and rupture during the progression of atherosclerosis. Foam cells are destined to divergent cell fate and functions in response to external stimuli based on their internal states, which however is hidden in the traditional ...

2023-09-08 | MTBLS6366 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
MetabolomicsMycobacterium tuberculosis VadK required for regulation of the methylcitrate cycle and virulence

The evolution of new enzymatic functions is constrained and guided by the architecture of an organism’s metabolic and regulatory networks and environmental constraints. Here, we identify a kinase that has evolved from pyruvate phosphate dikinase. Through biochemical and systems-lev...

2026-04-21 | MTBLS13906 | MetaboLights
TranscriptomicsTranscription profiling of human alveolar macrophages reveals overexpression of apoptotic cell removal receptor, MERTK,
Mononuclear phagocytes play an important role in the removal of apoptotic cells by expressing cell surface receptors that recognize and remove apoptotic cells. Based on the knowledge that cigarette smoking is associated with increased lung cell turnover, we hypothesized that alveolar macrophages (AM...
ORGANISM(S): Homo sapiens 
2008-10-18 | E-GEOD-8823 | biostudies-arrayexpress
MetabolomicsInteraction between Cervical Microbiota and Host Gene Regulation in Caesarean Section Scar Diverticulum

Cesarean section scar diverticulum (CSD) has become a formidable obstacle preventing women receiving CS from reproducing. However, the pathogenesis of CSD remains unexplored. In this study, we characterized the cervical microbiota, metabolome and endometrial transcriptome of women with CSD. Based...

2022-07-25 | MTBLS4967 | MetaboLights
ProteomicsRegulation of dendritic cells and macrophages by an anti-apoptotic cell natural Ab that inhibits inflammatory arthritis
Although natural antibodies (NAbs) are present from birth, little is known about what drives their selection, and whether they have housekeeping functions. We now show that the prototypic T15-NAb, first identified because of its protective role in infection, is representative of a previously unknown...
ORGANISM(S): unidentified 
2010-05-06 | E-GEOD-14969 | biostudies-arrayexpress
MetabolomicsAstaxanthin Protects Against Ferroptosis and Oxidative Stress via Retinoic Acid-Mediated SLC7A11 Regulation by Lepagella muris

Oxidative stress and ferroptosis are central to the pathogenesis of many diseases, including those characterized by intestinal damage, where excessive lipid peroxidation and iron accumulation trigger cellular dysfunction. In this study, we investigate the protective effects of astaxanthin (ASTA),...

2025-10-14 | MTBLS13140 | MetaboLights
TranscriptomicsHDAC Inhibitors induce tumor cell-selective pro-apoptotic transcriptional responses.
The identification of recurrent somatic mutations in genes encoding epigenetic enzymes, coupled with biochemical studies demonstrating aberrant recruitment of epigenetic enzymes such as histone deacetylases (HDACs) and histone methyltransferases (HMTs) to promoter regions through association with on...
ORGANISM(S): Homo sapiens 
2013-04-22 | E-GEOD-43010 | biostudies-arrayexpress
GenomicsAnti-apoptotic regulation contributes successful nuclear reprogramming using cryopreserved oocytes
Anti-apoptotic regulation contributes successful nuclear reprogramming using cryopreserved oocytes
PRJNA516198 | ENA
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