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TranscriptomicsChIP-seq of T/Brachyury in mouse embryonic stem cells in the process of disruption of naive pluripotency caused by T induction
ChIP-seq to clarify the molecular mechanism by which a mesodermal transcription factor, T/Brachyury, disrupts the defined naive pluripotency.
ORGANISM(S): Mus musculus 
2021-06-15 | E-MTAB-9490 | biostudies-arrayexpress
TranscriptomicsRNA-seq for evaluation of the disruption of pluripotency and the related differentiation program in mouse embryonic stem cell (mESC) models
RNA-seq to clarify the molecular mechanism by which a mesodermal transcription factor, T/Brachyury, disrupts the defined naive pluripotency and induce the concomitant differentiation program.
ORGANISM(S): Mus musculus 
2021-06-15 | E-MTAB-9494 | biostudies-arrayexpress
GenomicsA mesodermal factor, T (Brachyury), specifies mouse germ cell fate by directly activating germline determinants
Germ cells ensure reproduction and heredity in metazoans. Primordial germ cells (PGCs) in mice are induced in pluripotent epiblasts by BMP4 and WNT3, yet their mechanism of action remains unclear. Here, using in vitro PGC specification system, we show that WNT3 induces many transcription factors a...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-50394 | biostudies-arrayexpress
TranscriptomicsA Mesodermal Factor, T (BRACHYURY), specifies mouse germ cell fate by directly activating germline determinants.
The germ cell lineage ensures reproduction and heredity in metazoans. Primordial germ cells (PGCs) in mice are induced in pluripotent epiblast cells by BMP4 and WNT3, yet their mechanism of action remains elusive. Here, using in vitro PGC specification system, we show that WNT3, but not BMP4, induce...
ORGANISM(S): Mus musculus 
2013-12-11 | E-GEOD-49689 | biostudies-arrayexpress
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