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TranscriptomicsRNA-Seq of mouse E12.5 brain regions
Investigations into the roles for Pbx1 and its transcriptional network in dopaminergic neuron development and Parkinson's Disease Three samples each from dorsal midbrain, forebrain, hindbrain, Alar plate, and ventral midbrain
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82099 | biostudies-arrayexpress
GenomicsChIP-Seq for Pbx1 in the mouse E12.5 ventral midbrain
Investigations into the roles for Pbx1 and its transcriptional network in dopaminergic neuron development and Parkinson's Disease One sample each for Pbx1, IgG, and input
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82098 | biostudies-arrayexpress
TranscriptomicsStromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells
The identified stromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells. Human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons are potentially useful for treating Parkinson’s disease (PD) through cell replacement therapy. Gen...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-20503 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse neural stem cell lines overexpressing Nurr1 to clonal controls
The orphan nuclear receptor Nurr1 has been shown to be critical for the development of ventral midbrain dopaminergic neurons. Consequently, the development of ES cells overexpressing Nurr1 has raised hope for the development of cell replacement therapies for Parkinson's Disease to replace degenerate...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3571 | biostudies-arrayexpress
GenomicsSingle cell transcriptomics of hESC-derived midbrain dopaminergic neurons generated by a new human development-based protocol
Data Access Committee EGAC00001002707
EGAC00001002707 | EGA
TranscriptomicsSingle-cell RNA-seq of hESC (H9) lines exposed to a striatal differentiation protocol
Use of single-cell transcriptomics to measure how well medium spiny projection neurons, derived from human ESC, recapitulate human striatal development in vivo. This in vitro single-cell dataset was derived after exposing hESC lines (H9) to a novel striatal differentiation protocol and performing si...
ORGANISM(S): Homo sapiens 
2023-01-31 | E-MTAB-12080 | biostudies-arrayexpress
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