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ProteomicsAn impaired respiratory electron chain triggers retrograde response and de-ubiquitination of solute carrier amino acid transporters
Hundreds of genes have been associated with respiratory chain disease so far. Elimination of the respiratory electron chain by depleting the entire mitochondrial DNA (mtDNA, ��0 cells) has therefore one of the most severe impacts on the energy metabolism in eukaryotic cells. Here, we integrated prot...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD002270 | Pride
Proteome profiling Ρ0 cells Metabolome profiling Mass spectrometry Ubiquitination Retrograde response Oxphos deficiency 
ProteomicsAn impaired respiratory electron chain triggers down-regulation of the energy metabolism and de-ubiquitination of solute carrier amino acid transporters
We integrated metabolome and proteome profiles of the parental cell line 143B.TK- versus ?0, including PTM analyses such as phosphorylation and ubiquitination to characterize the impact of the absence of mtDNA for the entire cell. For quantitative proteome profiling, we used a shotgun LC-MS/MS appro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080873 | MassIVE
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