Sort   by:  
 Page size 
TranscriptomicsDNA methylation profiles of mouse sperm in response to antibiotic-induced gut microbiota dysbiosis using whole-genome bisulfite sequencing
DNA methylation profile of mouse sperm from conventionally-raised mice and gut dysbiosis experienced mice were characterized using whole-genome bisulfite sequencing. Genome-wide DNA methylation changes between control and dysbiotic male�s sperm were highly comparable, with no change in DNAme globall...
ORGANISM(S): Mus musculus 
2023-11-13 | E-MTAB-10033 | biostudies-arrayexpress
GenomicsGenomic profiling of offspring liver tissue in response to paternal gut microbiota dysbiosis using whole genome sequencing
Liver tissue samples were harvested from offspring sired by conventionally-raised male mice or dysbiotic sire, and profiled for genome changes using whole genome sequencing. F1 offspring samples were collected from six independent mating, and gDNA was extracted from offspring liver at postnatal day ...
ORGANISM(S): Mus musculus 
2023-11-13 | E-MTAB-10273 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of paternal testis and their offspring in response to gut microbiota dysbiosis using RNA sequencing analysis
Tissue samples harvested from conventionally-raised sire and their offspring or dysbiotic sire and their offspring were profiled for transcriptome changes using total RNA sequencing. Total RNA was extracted from four different tissue types: sire testis, F1 placenta (at E13.5 & E18.5), and F1 brain a...
ORGANISM(S): Mus musculus 
2023-11-13 | E-MTAB-10034 | biostudies-arrayexpress
MetabolomicsPaternal microbiome perturbations impact offspring fitness

The gut microbiota operates at the interface of host-environment interactions to influence human homeostasis and metabolic networks. Environmental factors that unbalance gut microbial ecosystems can therefore elicit physiological and disease-associated responses across somatic tissues. However, t...

2024-02-12 | MTBLS1629 | MetaboLights
Sort   by:  
 Page size