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TranscriptomicsTranscription profiling of normal and tumorigenic Rattus norvegicus cell lines grown under normal and arginine deprivation conditions
Goals of the Study:; 1. Assess the scope of arginine-responsive hepatic gene expression using in vitro rat models. 2. Compare normal and tumorigenic cells; 3. Identify potentially novel genes and pathways that may be subject to amino acid (arginine) regulation; Background: We previously reported t...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2275 | biostudies-arrayexpress
MetabolomicsNLRP3 Senses L-Arginine to Inhibit Inflammasome Activation and Alleviate Parkinson’s disease Pathology

We screened a series of metabolites and found that L-Arg strongly inhibits NLRP3 inflammasome assembly in vitro. Mechanistically, L-Arg directly binds the D31 site of NLRP3, blocking NLRP3-ASC interaction and subsequent inflammasome assembly. This discovery establishes NLRP3 as a direct sensor fo...

2026-09-02 | MTBLS13737 | MetaboLights
MetabolomicsThe response of Chlamydomonas reinhardtii to nitrogen deprivation: a systems biology analysis

Drastic alteration in macronutrients causes large changes in gene expression in the photosynthetic unicellular alga Chlamydomonas reinhardtii. Preliminary data suggested that cells follow a biphasic response to this change hinging on the initiation of lipid accumulation, and we hypothesized that ...

2015-06-29 | MTBLS208 | MetaboLights
ProteomicsArginine sensing in Leishmania
Abstract Protozoa of the genus Leishmania are the causative agents of leishmaniasis in humans. These parasites cycle between promastigotes in the sand fly mid-gut and amastigotes in phagolysosome of mammalian macrophages. During infection, they up-regulate host nitric oxide synthase and arginase exp...
ORGANISM(S): Leishmania donovani 
2016-04-11 | PXD002830 | Pride
Arginine sensing Phosphoproteome Leishmania 
ProteomicsArginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells
Proteomic changes following arginine deprivation in colorectal cancer cells before/after starvation were quantified with TMT mass spec
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD036737 | Pride
Arginine deprivation Colorectal cancer Tmt 
TranscriptomicsAn arginine sensing pathway in Leishmania induces a Mitogen-Activated Protein Kinase 2-mediated response during macrophage invasion
Protozoa of the genus Leishmania are the causative agents of leishmaniasis in humans. These parasites cycle between promastigotes in the sand fly mid-gut and amastigotes in phagolysosome of mammalian macrophages. During infection, host up-regulate nitric oxide synthase and parasite induce host argin...
ORGANISM(S): Leishmania donovani 
2016-08-01 | E-GEOD-71572 | biostudies-arrayexpress
GenomicsArginine deprivation of ASS1-deficient cancers drives mistranslation and neoepitope production
Arginine deprivation of ASS1-deficient cancers drives mistranslation and neoepitope production
PRJNA1333904 | ENA
GenomicsRibosome dynamics following arginine deprivation in colon cancer cells
Ribosome dynamics following arginine deprivation in colon cancer cells
PRJNA880902 | ENA
ProteomicsArginine deprivation of ASS1-deficient cancers drives mistranslation and shared neoepitope production
Arginine biosynthesis is frequently suppressed in human cancer due to loss of argininosuccinate synthetase 1 (ASS1) expression, rendering cancer cells reliant on extracellular arginine. This observation propelled the development of systemic arginine depletion strategies, which are clinically safe bu...
ORGANISM(S): Homo sapiens (Human) 
2026-04-28 | PXD068912 | Pride
GenomicsArginine deprivation of ASS1-deficient cancers drives mistranslation and neoepitope production [Ribo-Seq]
Arginine deprivation of ASS1-deficient cancers drives mistranslation and neoepitope production [Ribo-Seq]
PRJNA1333883 | ENA
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