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TranscriptomicsWhole mouse genome analysis of LCMV-specific CD4 and CD8 T cells throughout acute and chronic LCMV infection.
CD4 and CD8 T cells display functional defects during chronic infection such as loss of certain cytokines. Recent studies have suggested that CD4 T cells may actually gain other functions, however. Here, we analyzed gene expression profiles from LCMV-specific CD4 and CD8 T cells throughout the respo...
ORGANISM(S): Mus musculus 
2012-12-12 | E-GEOD-30431 | biostudies-arrayexpress
TranscriptomicsLongitudinal expression data from CD8+ T cells responding to LCMV-Armstrong or LCMV-Clone 13
During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections...
ORGANISM(S): Mus musculus 
2012-11-23 | E-GEOD-41867 | biostudies-arrayexpress
TranscriptomicsLongitudinal expression data from CD4+ T cells responding to LCMV-Armstrong or LCMV-Clone 13
During acute viral infections, naïve CD4+ T cells differentiate into effector CD4+ T cells and, after viral control, into memory CD4+ T cells. Memory CD4+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections...
ORGANISM(S): Mus musculus 
2014-10-24 | E-GEOD-41866 | biostudies-arrayexpress
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
UnknownThe biochemical mechanism of Rho GTPase membrane binding, activation and retention in activity patterning
Not available
S-SCDT-10_1038-S44318-025-00418-Z | biostudies-other
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
TranscriptomicsNovel Regions of Variable DNA Methylation in Human Placenta associated with Newborn Neurobehavioral Traits
Genome-wide profiling of placental DNA methylation in relation to neurobehavioral development. The Illumina 450k methylation array was used to profile 335 samples. These samples have been collected from the Rhode Island Child Health Study (RICHS). Illumina analysis performed on 335 human placentas
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-75248 | biostudies-arrayexpress
UnknownHospital costs in relation to body-mass index in 1·1 million women in England: a prospective cohort study.
Not available
S-EPMC6196771 | biostudies-literature
UnknownBody mass index and use and costs of primary care services among women aged 55-79 years in England: a cohort and linked data study.
Not available
S-EPMC6451629 | biostudies-literature
UnknownThe effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.
Not available
S-EPMC3145073 | biostudies-literature
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