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TranscriptomicsAnalysis of the DNA methylome and transcriptome in granulopoiesis reveal timed changes and dynamic enhancer methylation [expression]
The study investigated the changes in DNA-methylation and gene expression during granulopoiesis. To this end CMP, GMP, PMC and PMN cell populations were isolated by FACS from bonemarrow from healty donors and analysed by CAGE as well as expression and DNA microarrays total RNA was isolated from CMP,...
ORGANISM(S): Homo sapiens 
2014-04-29 | E-GEOD-49883 | biostudies-arrayexpress
TranscriptomicsThe epigenetic signature of systemic insulin resistance in obese women [BL]
Impaired ability of insulin to stimulate cellular glucose uptake and regulate metabolism, that is insulin resistance (IR), links adiposity to metabolic disorders such as type 2 diabetes (T2D), dyslipidemia and cardiovascular disease (Langenberg, 2012). Both genetic and epigenetic factors are implica...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-76285 | biostudies-arrayexpress
TranscriptomicsThe epigenetic signature of systemic insulin resistance in obese women [SC]
Impaired ability of insulin to stimulate cellular glucose uptake and regulate metabolism, that is insulin resistance (IR), links adiposity to metabolic disorders such as type 2 diabetes (T2D), dyslipidemia and cardiovascular disease (Langenberg, 2012). Both genetic and epigenetic factors are implica...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-76398 | biostudies-arrayexpress
TranscriptomicsThe epigenetic signature of systemic insulin resistance in obese women [OM]
Impaired ability of insulin to stimulate cellular glucose uptake and regulate metabolism, that is insulin resistance (IR), links adiposity to metabolic disorders such as type 2 diabetes (T2D), dyslipidemia and cardiovascular disease (Langenberg, 2012). Both genetic and epigenetic factors are implica...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-76394 | biostudies-arrayexpress
ProteomicsPCGF1-PRC1 safeguards recovery of nucleosome positioning during S-phase to ensure early hematopoiesis
Polycomb repressive complexes 1 and 2 (PRC1 and 2) repress lineage inappropriate genes during development to maintain proper cellular identities. To reveal the function of a variant PRC1 containing PCGF1 (PCGF1-PRC1), we prepared PCGF1 interacting proteins by immunoprecipitation and characterized th...
ORGANISM(S): Mus Musculus (mouse) 
2023-05-13 | PXD033883 | JPOST Repository
TranscriptomicsAnalysis of the DNA methylome and transcriptome in granulopoiesis reveal timed changes and dynamic enhancer methylation
The study investigated the changes in DNA-methylation and gene expression during granulopoiesis. To this end CMP, GMP, PMC and PMN cell populations were isolated by FACS from bone marrow from healthy donors and analysed by CAGE as well as expression and DNA microarrays. Bisulphite converted DNA from...
ORGANISM(S): Homo sapiens 
2014-03-27 | E-GEOD-50797 | biostudies-arrayexpress
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