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MetabolomicsPilot metabolomics study of aromatase inhibitor associated arthralgias
Not available
ORGANISM(S): Homo sapiens 
ST000695 | MetabolomicsWorkbench
TranscriptomicsExpression profiling of response to first-line aromatase inhibitor therapy
Fresh-frozen primary cancer specimens of 107 breast cancer patients whose metastases were treated with first-line aromatase inhibitors were evaluated for their whole genome mRNA expression profiles. Primary breast tumors (107) were analyzed against a common breast cancer reference pool (BRP).
ORGANISM(S): Homo sapiens 
2013-12-05 | E-GEOD-41994 | biostudies-arrayexpress
GenomicsGlobal mapping of estrogen receptor and histone modifications in breast tumor samples uncovers distinct patterns for aromatase inhibitor resistance
ChIP-seq on primary breast cancer tumor samples for Era, H3K4me3, H3K27me3. Patients had a poor or good outcome after aromatase inhibitor treatment. Differential binding patterns between good and poor outcome patients were identified for each marker, predicting response to treatment comparing ER, H3...
ORGANISM(S): Homo sapiens 
2013-12-05 | E-GEOD-40867 | biostudies-arrayexpress
TranscriptomicsGDNF-RET signaling as a target in aromatase inhibitor resistant breast cancers
Understanding the complex molecular mechanisms underlying resistance to endocrine therapy is a major challenge in the treatment of estrogen receptor-positive (ER+) breast cancers. We have previously demonstrated that glial cell line-derived neurotrophic factor (GDNF) signaling via the receptor tyros...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MEXP-3662 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human breast cancer biopsies taken before and after patients were treated with aromatase inhibitors
Molecular response to Aromatase Inhibitor Treatment in Primary Breast Cancer
ORGANISM(S): Homo sapiens 
2007-11-29 | E-TABM-180 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human estrogen receptor positive MCF7 cells stably transfected with aromatase gene treated with testosterone, 17 B-estradiol, two aromatase inhibitors (letrozole and anastrozole), and an anti-estrogen (tamoxifen)
Anti-estrogens and aromatase inhibitors are important drugs in the treatment of estrogen-dependent breast cancer. In order to investigate the effects of these drugs on gene expression in breast cancer cells, we treated estrogen receptor-positive MCF-7 cells, stably transfected with the aromatase ge...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2225 | biostudies-arrayexpress
GenomicsEstrogen Receptor Positive Breast Cancer: Aromatase Inhibitor Response Study

Highly variable outcomes are observed in patients with estrogen receptor positive (ER+) breast cancer who undergo preoperative estrogen deprivation therapy with aromatase inhibitors (AI). In this study, 46 tumor and normal genomes and 31 exomes of participants selected from two clinical trials of...

phs000472.v1.p1 | EGA
TranscriptomicsThe gene expression of aromatase-inhibitor-resistant cell line
To identify the genes which have relation to aromatase-inhibitor-resistance, we compared the gene expression of aromatase-inhibitor-resistant cell, A3, with that of parent cell line, T-47D. Because A3 showed remarkable cell proliferation by 1nM Dihydrotestosterone(DHT), cells were cultured with DHTa...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-51390 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of aromatase-inhibitor-resistant breast cancer cell lines derived from T-47D
To identify the genes which have relation to aromatase-inhibitor-resistance, we compared the gene expression of aromatase-inhibitor-resistant cell, A3, with that of parent cell line, T-47D.
ORGANISM(S): Homo sapiens 
2014-04-01 | E-MTAB-1933 | biostudies-arrayexpress
TranscriptomicsLacrimal Gland Gene expression in Aromatase Knockout Mice and Wild Type Controls
The Effect of Aromatase Knockout on Gene Expression in the Mouse Lacrimal and Meibomoan Gland. Keywords: Aromatase Knockout vs Wild Type Control Lacrimal and meibomian glands were harvested from homozygous male and female aromatase knockout mice and age matched wild type controls. Tissues were poole...
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-5878 | biostudies-arrayexpress
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