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ProteomicsAn atypical Arp2/3 complex is required for Plasmodium DNA segregation and transmission of malaria.
Plasmodium parasites, the causative agents of malaria, undergo crucial developments within the mosquito vector, initiated by the formation of male and female gametes from gametocytes. Male gametogenesis involves three rapid rounds of endomitosis followed by a single round of DNA segregation and nucl...
ORGANISM(S): Mus musculus (Mouse) Plasmodium berghei 
2025-04-22 | PXD060997 | Pride
Arp2/3 complex Chromosome segregation Malaria Plasmodium 
ProteomicsA non-canonical Arp2/3 complex is essential for Plasmodium DNA segregation and transmission of malaria.
The malaria-causing parasite Plasmodium has a complex life cycle involving both vertebrate and mosquito hosts. Sexual stages or gametocytes are the only stage competent for mosquito transmission. Gametogenesis of the male gametocyte requires rapid rounds of genome replication to form flagellated gam...
ORGANISM(S): Plasmodium berghei 
2025-04-22 | PXD051260 | Pride
Arp2/3 complex Chromosome segregation Malaria Plasmodium 
ProteomicsA non-canonical Arp2/3 complex is essential for Plasmodium DNA segregation and transmission of malaria.
The malaria-causing parasite Plasmodium has a complex life cycle involving both vertebrate and mosquito hosts. Sexual stages or gametocytes are the only stage competent for mosquito transmission. Gametogenesis of the male gametocyte requires rapid rounds of genome replication to form flagellated gam...
ORGANISM(S): Plasmodium berghei 
2025-04-22 | PXD046181 | Pride
Arp2/3 complex Chromosome segregation Malaria Plasmodium 
ProteomicsmTORC1 and mTORC2 converge on the Arp2/3 complex to promote KrasG12D-induced acinar-to-ductal metaplasia and early pancreatic carcinogenesis
Oncogenic KrasG12D, a driver mutation of pancreatic ductal adenocarcinoma (PDAC), induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM). Here, we show that both functional complexes of mTOR (mechanistic target of rapamycin kinase, mTORC1 and mTORC2) are specific...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-07 | PXD018296 | Pride
Pancreatic cancer  adm  arp2/3 complex  mtor  actin rearrangement 
GenomicsThe Arp2/3 complex controls the development of homeostatic microglia
The Arp2/3 complex controls the development of homeostatic microglia
PRJNA1218719 | ENA
TranscriptomicsThe Arp2/3 complex controls the development of homeostatic microglia
Microglia are the major brain-resident immune cell subsetthat areessential during pathology and physiology in the central nervous system. The regulation of functional elementsrequired for microglialhomeostasis needsto be precisely orchestrated.To date, the underlying mechanismshave not been fully in...
ORGANISM(S): Mus musculus 
2026-01-31 | GSE288625 | GEO
GenomicsArp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification
Arp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification
PRJNA732213 | ENA
GenomicsArp2/3 Complex Activity Enables Nuclear YAP for Naïve Pluripotency of Human Embryonic Stem Cells
Arp2/3 Complex Activity Enables Nuclear YAP for Naïve Pluripotency of Human Embryonic Stem Cells
PRJNA1159843 | ENA
GenomicsThe Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells
The Arp2/3 complex maintains genome integrity and survival of epidermal Langerhans cells
PRJNA1217845 | ENA
TranscriptomicsArp2/3 complex activity is necessary for mouse ESC differentiation, times formative pluripotency, and enables lineage specification
Mouse embryonic stem cells (mESCs), a model for differentiation into primed epiblast-like cells (EpiLCs), have revealed transcriptional and epigenetic control of early embryonic development. The control and significance of morphological changes, however, remain less defined. We show marked changes i...
ORGANISM(S): Mus musculus 
2022-04-01 | GSE175391 | GEO
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