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TranscriptomicsExpression profiling of LSK cells from Bmi1 cKO mice in hematopoiesis versus LSK control cells from WT mice
Bmi1 is a protein member of PRC1 and plays a major role in the maintenance of gene repression. We are studying the role of Bmi1 in the context of hematopoietic stem cell aging. We used microarray to study the gene expression profile of LSK cells in relation to the knocking-out of Bmi1 in vivo LSK ce...
ORGANISM(S): Mus musculus 
2011-10-29 | E-GEOD-31404 | biostudies-arrayexpress
TranscriptomicsSympathetic neuropathy of the bone marrow haematopoietic stem cell niche is essential for myeloproliferative neoplasms
Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the haematopoietic stem cell (HSC) compartment. Most MPN patients have a common acquired mutation of Janus kinase 2 (JAK2) gene in HSCs that renders this kinase constitutively active, leading to uncontrolled cell expansion. The ...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55801 | biostudies-arrayexpress
TranscriptomicsNeuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55802 | biostudies-arrayexpress
TranscriptomicsNeuropathy of the haematopoietic stem cell niche is essential for myeloproliferative neoplasms [RNA-seq]
Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the haematopoietic stem cell (HSC) compartment. Most MPN patients have a common acquired mutation of Janus kinase 2 (JAK2) gene in HSCs that renders this kinase constitutively active, leading to uncontrolled cell expansion. The ...
ORGANISM(S): Mus musculus 
2014-03-12 | E-GEOD-55798 | biostudies-arrayexpress
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