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TranscriptomicsRNA-seq of CN, CN/AML, and CN/AML BAALC KO iPSCs-derived HSPCs
Severe congenital neutropenia (CN) is a pre-leukemia syndrome that, in the majority of patients, is caused by heterogeneous ELANE mutations encoding neutrophil elastase (NE). To study leukemogenesis associated with CN we generated CN and CN/AML patient-specific induced pluripotent stem cells (iPSCs)...
ORGANISM(S): Homo sapiens 
2021-03-08 | E-MTAB-10162 | biostudies-arrayexpress
GenomicsEpo-Induced Erythroid Maturation Is Dependent on Plcγ1 Signaling
Erythropoiesis is a tightly regulated process. Development of red blood cells occurs through differentiation of hematopoietic stem cells into more committed progenitors and finally into erythrocytes. Binding of erythropoietin to its receptor (EpoR) is strictly required for erythropoiesis as it promo...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-60087 | biostudies-arrayexpress
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